Shell-sheddable (ShS) nanoassemblies based on well-defined amphiphilic block copolymers (ABPs) exhibiting stimuli-responsive degradation (SRD) have been extensively investigated for the detachment of the poly(ethylene glycol) corona as tumor-targeting drug delivery systems. They are designed to respond to triggers found in the cellular environment while being stable under physiological conditions. Particular interest is their responses to the tumor acidic environment (pH = 4.7–6.5) and glutathione (GSH) present in the cytosol of tumor tissues. Moreover, dual-location ShS nanoassemblies have been explored with endogenous acidic pH and GSH stimuli to achieve enhanced/accelerated, systematic drug release profiles in the complex tumor environment. This review summarizes the recent advances in synthetic strategies for single-location ShS ABP nanoassemblies and advanced strategies for dual-location ShS/core-degradable ABP nanoassemblies, focusing on their acidic pH and GSH-responsive degradation. Furthermore, the benefits and drawbacks of these nanoassemblies in biological aspects and outlooks for effective tumor-targeting drug delivery are discussed.

中文翻译：

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用于药物输送的酸/谷胱甘肽可降解嵌段共聚物纳米组件的合成和可脱壳分解的最新进展


基于具有刺激响应性降解（SRD）的明确两亲性嵌段共聚物（ABP）的可脱壳（ShS）纳米组件已被广泛研究用于聚（乙二醇）冠的分离作为肿瘤靶向药物输送系统。它们旨在响应细胞环境中发现的触发因素，同时在生理条件下保持稳定。特别令人感兴趣的是它们对肿瘤酸性环境（pH = 4.7-6.5）和肿瘤组织细胞质中存在的谷胱甘肽（GSH）的反应。此外，人们还利用内源性酸性 pH 和 GSH 刺激探索了双位 ShS 纳米组件，以在复杂的肿瘤环境中实现增强/加速、系统的药物释放曲线。本综述总结了单位置 ShS ABP 纳米组件的合成策略和双位置 ShS/核心可降解 ABP 纳米组件的先进策略的最新进展，重点关注其酸性 pH 和 GSH 响应性降解。此外，还讨论了这些纳米组件在生物学方面的优点和缺点以及有效的肿瘤靶向药物递送的前景。