Medulloblastoma is a heterogeneous embryonal tumor of the cerebellum comprised of four distinct molecular subgroups that differ in their developmental origins, genomic landscapes, clinical presentation, and survival. Recent characterization of the human fetal cerebellum at single-cell resolution has propelled unprecedented insights into the cellular origins of medulloblastoma subgroups, including those underlying previously elusive groups 3 and 4. In this review, the molecular pathogenesis of medulloblastoma is examined through the lens of cerebellar development. In addition, we discuss how enhanced understanding of medulloblastoma origins has the potential to refine disease modeling for the advancement of treatment and outcomes.

中文翻译：

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发育停滞：髓母细胞瘤的功能失调的生活史


髓母细胞瘤是小脑的一种异质性胚胎肿瘤，由四个不同的分子亚群组成，这些亚群在发育起源、基因组景观、临床表现和生存方面有所不同。最近在单细胞分辨率下对人类胎儿小脑的表征推动了对髓母细胞瘤亚组细胞起源的前所未有的了解，包括以前难以捉摸的第 3 组和第 4 组细胞起源。在这篇综述中，通过小脑的镜头检查了髓母细胞瘤的分子发病机制。发展。此外，我们还讨论了增强对髓母细胞瘤起源的了解如何有可能完善疾病模型，以促进治疗和结果的进展。