6:2 Chlorinated polyfluorinated ether sulfonate, commonly known as F-53B, is widely used as a mist suppressant in various industries and is frequently detected in the environment. Despite its prevalent presence, the adverse effects of F-53B are not well understood and require future investigation. This study utilized zebrafish embryos and adults to examine the toxic effects of F-53B. Our findings revealed that F-53B impaired gill structure and increased erythrocyte numbers in adult zebrafish. Notably, F-53B demonstrated a higher sensitivity for inducing mortality (LC at 96 h) in adult zebrafish compared to embryos. Additionally, F-53B disrupted the expression of critical steroidogenic genes and hindered sex hormone production, which negatively affecting egg production. In conclusion, this study underscores the detrimental impact of F-53B on gill structure and reproductive toxicity in zebrafish, providing valuable insights into its overall toxicity.

中文翻译：

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新型氯化多氟醚磺酸盐 F-53B 对斑马鱼鳃结构和生殖毒性的影响


6:2氯化多氟醚磺酸盐，俗称F-53B，广泛用作各行业的抑雾剂，在环境中经常被检测到。尽管 F-53B 普遍存在，但其不利影响尚未得到充分了解，需要进一步调查。这项研究利用斑马鱼胚胎和成体来检查 F-53B 的毒性作用。我们的研究结果表明，F-53B 会损害成年斑马鱼的鳃结构并增加红细胞数量。值得注意的是，与胚胎相比，F-53B 在诱导成年斑马鱼死亡（96 小时时的 LC）方面表现出更高的敏感性。此外，F-53B 破坏了关键类固醇生成基因的表达并阻碍性激素的产生，从而对产蛋产生负面影响。总之，这项研究强调了 F-53B 对斑马鱼鳃结构和生殖毒性的有害影响，为其整体毒性提供了有价值的见解。