The C-terminal amino acid motifs of NS1 protein affect the replication and virulence of naturally NS-truncated H1N1 canine influenza virus,Emerging Microbes & Infections

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The C-terminal amino acid motifs of NS1 protein affect the replication and virulence of naturally NS-truncated H1N1 canine influenza virus
Emerging Microbes & Infections ( IF 8.4 ) Pub Date : 2024-09-13 , DOI: 10.1080/22221751.2024.2400546
Pingping Wang _{1,

2,

3} , Jianing Guo ₁ , Yefan Zhou _{1,

2,

3} , Min Zhu _{1,

2,

3} , Senbiao Fang _{4,

5} , Fanyuan Sun _{1,

2,

3} , Chongqiang Huang _{1,

2,

3} , Yaohui Zhu _{1,

2,

3} , Huabo Zhou ₆ , Boyu Pan _{4,

5} , Yifeng Qin _{1,

2,

3} , Kang Ouyang _{1,

2,

3} , Zuzhang Wei _{1,

2,

3} , Weijian Huang _{1,

2,

3} , Adolfo García-Sastre _{7,

8,

9} , Ying Chen _{1,

2,

3}

Affiliation

Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, People's Republic of China.
Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.
Guangxi Key Laboratory of Animal Breeding, Disease Prevention and Control, Nanning, People's Republic of China.
Department of Molecular Pharmacology, Tianjin Medical University Cancer Institute & Hospital, Tianjin, People's Republic of China.
National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin Clinical Research Center for Cancer, Tianjin, People's Republic of China.
Huabo Pet Hospital, Nanning, People's Republic of China.
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

The vast majority of data obtained from sequence analysis of influenza A viruses (IAVs) have revealed that nonstructural 1 (NS1) proteins from H1N1 swine, H3N8 equine, H3N2 avian and the correspond...

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