OBJECTIVE To determine the annual incidence of psoriatic arthritis (PsA) in a United Kingdom primary care population with preexisting psoriasis (PsO) followed prospectively over 2 years after excluding baseline prevalence of existing disease. METHODS Total Burden of Psoriasis (TUDOR; ISRCTN registry: ISRCTN38877516) was a multicenter, prospective, 2-arm parallel-group cluster randomized controlled trial of the early identification of PsA by annual rheumatological assessment (termed "Enhanced Surveillance") vs standard care in people with PsO identified in primary care. Incidence of PsA is reported at 12 months and 24 months using patients from the Enhanced Surveillance arm, which allows for the exclusion of patients with prevalent PsA at baseline. RESULTS Fourteen of 511 participants attending a 12-month screen developed PsA over that interval, giving an incidence of 2.74/100 patient-years (PYs; 95% CI 1.32-4.16). Another 7/444 participants attending the 24-month visit developed PsA, giving an incidence of 1.58/100 PYs (95% CI 0.42-2.74). The combined incidence over 2 years was 2.20/100 PYs (95% CI 1.27-3.13). CONCLUSION The estimated annual incidence of PsA over a 2-year period was 2.20/100 PYs, which is in keeping with studies including clinical assessment rather than relying on health records alone. Extended follow-up of the TUDOR cohort with accrual of larger numbers of incident cases will allow risk factors for PsA to be explored in more depth.

中文翻译：

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英国初级保健银屑病人群中银屑病关节炎的发病率。


目的 确定在排除现有疾病的基线患病率后，前瞻性随访 2 年多的既往银屑病关节炎 （PsA） 初级保健人群银屑病关节炎 （PsA） 的年发病率。方法 银屑病总负担 （TUDOR;ISRCTN 注册库：ISRCTN38877516） 是一项多中心、前瞻性、双臂平行组整群随机对照试验，通过年度风湿病学评估（称为“加强监测”）与标准护理在初级保健中发现的 PsO 患者早期识别 PsA。使用来自加强监测组的患者在 12 个月和 24 个月时报告 PsA 的发生率，这允许排除基线时 PsA 普遍存在的患者。结果 参加 12 个月筛查的 511 名参与者中有 14 名在该间隔内发生 PsA，发生率为 2.74/100 患者年 （PY;95% CI 1.32-4.16）。另外 7/444 参加 24 个月访视的参与者患上了 PsA，发生率为 1.58/100 PYs（95% CI 0.42-2.74）。2 年的综合发病率为 2.20/100 PYs （95% CI 1.27-3.13）。结论 2 年期间 PsA 的估计年发病率为 2.20/100 PYs，这与包括临床评估在内的研究一致，而不是仅依赖健康记录。随着大量事件病例的积累，对 TUDOR 队列进行扩展随访，将允许更深入地探索 PsA 的危险因素。