OBJECTIVE Despite treatment advances, pain remains a serious problem for many children with juvenile idiopathic arthritis (JIA). To better understand pain in children with JIA and identify potentially modifiable factors, this study evaluated Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric Pain Interference (PI) and its relationships with other pain measures and demographic, clinical, psychosocial, and functional variables. METHODS This cross-sectional, observational, multicenter study used descriptive statistics and a mix of bivariate and multivariable analyses to describe PI and characterize relationships with other measures and variables. RESULTS Among 355 children with JIA, 27% reported moderate or severe PI and 13.3% reported daily pain. PI correlated with other pain measures. Increasing age, decreasing disease duration, and increasing number of active joints, as well as presence of active disease, steroid treatment, and biologic treatment, were associated with greater PI. All PROMIS psychosocial and functional measures were associated with PI in the expected direction except for PROMIS Pediatric Physical Activity, which showed no association. In multivariable analyses, only PROMIS Fatigue, PROMIS Mobility, and the exploratory interaction of PROMIS Anxiety and disease-modifying antirheumatic drug treatment were significant. CONCLUSION Moderate and severe PI was prevalent in this sample of children with JIA. PI increased with age and indicators of disease activity, but was more strongly associated with increasing fatigue and decreasing mobility. Findings support the use of PI as a short, easily administered multidimensional pain measure as part of routine clinical care. Fatigue, mobility, and disease activity should be assessed further when PI is high.

中文翻译：

---

幼年特发性关节炎的疼痛干扰。


目的 尽管治疗取得了进展，但疼痛仍然是许多幼年特发性关节炎 （JIA） 患儿的严重问题。为了更好地了解 JIA 患儿的疼痛并确定潜在的可改变因素，本研究评估了患者报告结果测量信息系统 （PROMIS） 儿科疼痛干扰 （PI） 及其与其他疼痛测量和人口统计学、临床、社会心理和功能变量的关系。方法 这项横断面、观察性、多中心研究使用描述性统计和双变量和多变量分析的混合来描述 PI 并描述与其他测量和变量的关系。结果 在 355 例 JIA 患儿中，27% 报告中度或重度 PI，13.3% 报告每日疼痛。PI 与其他疼痛指标相关。年龄增加、病程缩短、活动关节数量增加，以及活动性疾病、类固醇治疗和生物治疗的存在，与更大的 PI 相关。所有 PROMIS 社会心理和功能测量均在预期方向上与 PI 相关，但 PROMIS 儿科身体活动除外，该活动显示没有关联。在多变量分析中，只有 PROMIS 疲劳、PROMIS 活动性以及 PROMIS 焦虑和改善疾病的抗风湿药物治疗的探索性相互作用是显著的。结论 中度和重度 PI 在该 JIA 患儿样本中普遍存在。PI 随着年龄和疾病活动指标的增加而增加，但与疲劳增加和活动能力下降的相关性更强。研究结果支持将 PI 用作一种简短、易于管理的多维疼痛测量方法，作为常规临床护理的一部分。 当 PI 较高时，应进一步评估疲劳、活动能力和疾病活动度。