Limbal stem cell deficiency (LSCD) secondary to ocular surface alkali burn is a blinding condition that features corneal conjunctivalization. Mechanistic insights into its pathophysiology are lacking. Here, we developed a mouse model that recapitulates human disease to comprehensively delineate the clinicopathological features of a conjunctivalized cornea.

中文翻译：

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碱诱导的角膜缘干细胞缺陷临床前小鼠模型的开发和表征


继发于眼表碱烧伤的角膜缘干细胞缺陷 （LSCD） 是一种以角膜结膜形成为特征的致盲疾病。缺乏对其病理生理学的机制见解。在这里，我们开发了一个小鼠模型，该模型概括了人类疾病，以全面描绘结膜角膜的临床病理特征。