Development of novel treatments for celiac disease is dependent on precise tools to monitor changes in gluten-induced mucosal damage. Current histology measures are subjective and difficult to standardize. Biopsy proteome scoring is an objective alternative to histology which is based on robust changes in biological pathways that directly reflect gluten-induced mucosal damage. In this study, we aimed to evaluate biopsy proteome scoring as an effect measure in a clinical trial setting by measuring intestinal remodeling in response to oral gluten challenge.

中文翻译：

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活检蛋白质组评分在乳糜泻的麸质挑战试验中作为效果测量表现良好


乳糜泻新疗法的开发取决于精确的工具来监测麸质诱导的粘膜损伤的变化。目前的组织学测量是主观的，难以标准化。活检蛋白质组评分是组织学的客观替代方案，它基于直接反映麸质诱导的粘膜损伤的生物途径的稳健变化。在这项研究中，我们旨在通过测量对口服麸质攻击的肠道重塑来评估活检蛋白质组评分作为临床试验环境中的效果测量。