Acid secretion inhibitors are associated with hypergastrinemia, which can lead to gastric mucosal changes. Potassium-competitive acid blockers, such as vonoprazan, are more potent than proton pump inhibitors, but long-term safety data are lacking.

中文翻译：

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Vonoprazan 作为糜烂性食管炎的长期维持治疗：VISION，一项为期 5 年、随机、开放标签的研究


胃酸分泌抑制剂与高胃泌素血症有关，可导致胃粘膜变化。钾竞争性酸阻滞剂，如沃诺拉赞，比质子泵抑制剂更有效，但缺乏长期安全性数据。