Persons who work in close contact with dairy cattle and poultry that are infected with highly pathogenic avian influenza (HPAI) A(H5N1) virus are at increased risk for infection. In July 2024, the Colorado Department of Public Health & Environment responded to two poultry facilities with HPAI A(H5N1) virus detections in poultry. Across the two facilities, 663 workers assisting with poultry depopulation (i.e., euthanasia) received screening for illness; 109 (16.4%) reported symptoms and consented to testing. Among those who received testing, nine (8.3%) received a positive influenza A(H5) virus test result, and 19 (17.4%) received a positive SARS-CoV-2 test result. All nine workers who received positive influenza A(H5) test results had conjunctivitis, experienced mild illness, and received oseltamivir. This poultry exposure-associated cluster of human cases of influenza A(H5) is the first reported in the United States. The identification of these cases highlights the ongoing risk to persons who work in close contact with infected animals. Early response to each facility using multidisciplinary, multilingual teams facilitated case-finding, worker screening, and treatment. As the prevalence of HPAI A(H5N1) virus clade 2.3.4.4b genotype B3.13 increases, U.S. public health agencies should prepare to rapidly investigate and respond to illness in agricultural workers, including workers with limited access to health care.

中文翻译：

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2024 年 7 月，科罗拉多州两个设施发生与家禽接触相关的 A(H5) 流感集群病例。


与感染高致病性禽流感 (HPAI) A(H5N1) 病毒的奶牛和家禽密切接触的人员感染风险增加。 2024 年 7 月，科罗拉多州公共卫生与环境部对两家家禽设施进行了回应，在家禽中检测到 HPAI A(H5N1) 病毒。在这两个设施中，有 663 名协助家禽减少（即安乐死）的工作人员接受了疾病筛查； 109 人 (16.4%) 报告了症状并同意接受检测。在接受检测的人中，9人（8.3%）的甲型（H5）流感病毒检测结果呈阳性，19人（17.4%）的SARS-CoV-2检测结果呈阳性。所有九名甲型（H5）流感检测结果呈阳性的工人均患有结膜炎，病情较轻，并接受了奥司他韦治疗。这起与家禽暴露相关的人类甲型流感 (H5) 病例群是美国首次报告。这些病例的发现凸显了与受感染动物密切接触的工作人员所面临的持续风险。使用多学科、多语言团队对每个设施进行早期响应，促进了病例发现、工人筛查和治疗。随着 HPAI A(H5N1) 病毒分支 2.3.4.4b 基因型 B3.13 的流行增加，美国公共卫生机构应做好准备，迅速调查和应对农业工人（包括获得医疗保健机会有限的工人）的疾病。