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Post-translational modifications in the Protein Data Bank.
Acta Crystallographica Section D ( IF 2.6 ) Pub Date : 2024-08-29 , DOI: 10.1107/s2059798324007794
Lucy C Schofield 1 , Jordan S Dialpuri 1 , Garib N Murshudov 2 , Jon Agirre 1
Acta Crystallographica Section D ( IF 2.6 ) Pub Date : 2024-08-29 , DOI: 10.1107/s2059798324007794
Lucy C Schofield 1 , Jordan S Dialpuri 1 , Garib N Murshudov 2 , Jon Agirre 1
Affiliation
Proteins frequently undergo covalent modification at the post-translational level, which involves the covalent attachment of chemical groups onto amino acids. This can entail the singular or multiple addition of small groups, such as phosphorylation; long-chain modifications, such as glycosylation; small proteins, such as ubiquitination; as well as the interconversion of chemical groups, such as the formation of pyroglutamic acid. These post-translational modifications (PTMs) are essential for the normal functioning of cells, as they can alter the physicochemical properties of amino acids and therefore influence enzymatic activity, protein localization, protein-protein interactions and protein stability. Despite their inherent importance, accurately depicting PTMs in experimental studies of protein structures often poses a challenge. This review highlights the role of PTMs in protein structures, as well as the prevalence of PTMs in the Protein Data Bank, directing the reader to accurately built examples suitable for use as a modelling reference.
中文翻译:
蛋白质数据库中的翻译后修饰。
蛋白质经常在翻译后水平经历共价修饰,这涉及化学基团与氨基酸的共价连接。这可能需要单个或多个小基团的添加,例如磷酸化;长链修饰,例如糖基化;小蛋白质,例如泛素化;以及化学基团的相互转化,例如焦谷氨酸的形成。这些翻译后修饰 (PTM) 对于细胞的正常功能至关重要,因为它们可以改变氨基酸的理化性质,从而影响酶活性、蛋白质定位、蛋白质-蛋白质相互作用和蛋白质稳定性。尽管其固有的重要性,但在蛋白质结构的实验研究中准确描述 PTM 通常会带来挑战。这篇综述强调了 PTM 在蛋白质结构中的作用,以及 PTM 在蛋白质数据库中的普遍性,指导读者准确构建适合用作建模参考的示例。
更新日期:2024-09-01
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
蛋白质数据库中的翻译后修饰。
蛋白质经常在翻译后水平经历共价修饰,这涉及化学基团与氨基酸的共价连接。这可能需要单个或多个小基团的添加,例如磷酸化;长链修饰,例如糖基化;小蛋白质,例如泛素化;以及化学基团的相互转化,例如焦谷氨酸的形成。这些翻译后修饰 (PTM) 对于细胞的正常功能至关重要,因为它们可以改变氨基酸的理化性质,从而影响酶活性、蛋白质定位、蛋白质-蛋白质相互作用和蛋白质稳定性。尽管其固有的重要性,但在蛋白质结构的实验研究中准确描述 PTM 通常会带来挑战。这篇综述强调了 PTM 在蛋白质结构中的作用,以及 PTM 在蛋白质数据库中的普遍性,指导读者准确构建适合用作建模参考的示例。