function. This defense of systemic calcium homeostasis comes, however, at the expense of the dumping of calcium into the kidney tissue and urine. Because of the large size and multivalency of the calcium ion, its salts are the least soluble among all the major cations in the body. The potential pathologic consequences of this are nephrocalcinosis and kidney stone disease. In this review, we discuss recent advances that have highlighted critical roles for the proximal tubule and thick ascending limb in renal calcium reabsorption, elucidated the molecular mechanisms for paracellular transport in these segments, and implicated disturbances in these processes in human disease....

中文翻译：

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细胞旁转运和肾小管钙处理：在肾结石病中的新作用


功能。然而，这种对全身钙稳态的防御是以牺牲钙倾倒到肾脏组织和尿液中为代价的。由于钙离子的体积大、多价性强，其盐类在体内所有主要阳离子中是最难溶解的。其潜在的病理后果是肾钙质沉着症和肾结石病。在这篇综述中，我们讨论了最近的进展，这些进展强调了近端肾小管和粗升肢在肾钙重吸收中的关键作用，阐明了这些节段中细胞旁转运的分子机制，并暗示了人类疾病中这些过程的干扰。