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GLP-1 Receptor Agonists Among Patients With Overweight or Obesity, Diabetes, and HFpEF on SGLT2 Inhibitors
JACC: Heart Failure ( IF 10.3 ) Pub Date : 2024-08-28 , DOI: 10.1016/j.jchf.2024.07.006 Rushin Patel 1 , Mark Wadid 1 , Bhargav Makwana 1 , Ashish Kumar 2 , Sumanth Khadke 1 , Ammar Bhatti 1 , Ahan Banker 1 , Zaid Husami 1 , Sherif Labib 1 , David Venesy 1 , Gregg Fonarow 3 , Mikhail Kosiborod 4 , Sadeer Al-Kindi 5 , Deepak L Bhatt 6 , Sourbha Dani 1 , Anju Nohria 7 , Javed Butler 8 , Sarju Ganatra 1
JACC: Heart Failure ( IF 10.3 ) Pub Date : 2024-08-28 , DOI: 10.1016/j.jchf.2024.07.006 Rushin Patel 1 , Mark Wadid 1 , Bhargav Makwana 1 , Ashish Kumar 2 , Sumanth Khadke 1 , Ammar Bhatti 1 , Ahan Banker 1 , Zaid Husami 1 , Sherif Labib 1 , David Venesy 1 , Gregg Fonarow 3 , Mikhail Kosiborod 4 , Sadeer Al-Kindi 5 , Deepak L Bhatt 6 , Sourbha Dani 1 , Anju Nohria 7 , Javed Butler 8 , Sarju Ganatra 1
Affiliation
Although the use of glucagon-like peptide-1 receptor agonist (GLP-1 RA) in patients with obesity and heart failure with preserved ejection fraction (HFpEF) has demonstrated improvement in cardiovascular outcomes, the incremental benefits of GLP-1 RA for patients already on sodium-glucose cotransporter 2 inhibitors (SGLT2is) remain underexplored.
中文翻译:
GLP-1 受体激动剂在超重或肥胖、糖尿病和接受 SGLT2 抑制剂治疗的 HFpEF 患者中
尽管胰高血糖素样肽-1 受体激动剂 (GLP-1 RA) 在肥胖和射血分数保留 (HFpEF) 心力衰竭患者中的使用已证明心血管结局有所改善,但 GLP-1 RA 对已经使用钠-葡萄糖协同转运蛋白 2 抑制剂 (SGLT2is) 的患者的增量益处仍未得到充分探索。
更新日期:2024-08-28
中文翻译:
GLP-1 受体激动剂在超重或肥胖、糖尿病和接受 SGLT2 抑制剂治疗的 HFpEF 患者中
尽管胰高血糖素样肽-1 受体激动剂 (GLP-1 RA) 在肥胖和射血分数保留 (HFpEF) 心力衰竭患者中的使用已证明心血管结局有所改善,但 GLP-1 RA 对已经使用钠-葡萄糖协同转运蛋白 2 抑制剂 (SGLT2is) 的患者的增量益处仍未得到充分探索。