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An ultrathin organic–inorganic integrated device for optical biomarker monitoring
Nature Electronics ( IF 33.7 ) Pub Date : 2024-09-03 , DOI: 10.1038/s41928-024-01237-6
Kyung Yeun Kim , Joohyuk Kang , Sangmin Song , Kyungwoo Lee , Suk-Won Hwang , Seung Hwan Ko , Hojeong Jeon , Jae-Hoon Han , Wonryung Lee

Organic electrochemical transistors can be used in wearable sensors to amplify biological signals. Other wireless communication systems are required for applications in continuous health monitoring. However, conventional wireless communication circuits, which are based on inorganic integrated chips, face limitations in terms of conformability due to the thick and rigid integrated circuit chips. Here, we report an ultrathin organic–inorganic device for wireless optical monitoring of biomarkers, such as glucose in sweat and glucose, lactate and pH in phosphate-buffered saline. The conformable system integrates an organic electrochemical transistor and a near-infrared inorganic micro-light-emitting diode on a thin parylene substrate. The device has an overall thickness of 4 μm. The channel current of the transistor changes according to the biomarker concentration, which alters the irradiance from the light-emitting diode to enable biomarker monitoring. We combine the device with an elastomeric battery circuit to create a wearable patch. We also show that the system can be used for near-infrared image analysis.



中文翻译:


用于光学生物标志物监测的超薄有机-无机集成装置



有机电化学晶体管可用于可穿戴传感器来放大生物信号。连续健康监测的应用需要其他无线通信系统。然而,基于无机集成芯片的传统无线通信电路由于厚且刚性的集成电路芯片而在一致性方面面临限制。在这里,我们报告了一种超薄有机-无机设备,用于生物标记物的无线光学监测,例如汗液中的葡萄糖和磷酸盐缓冲盐水中的葡萄糖、乳酸和 pH 值。该顺应系统在薄聚对二甲苯基板上集成了有机电化学晶体管和近红外无机微型发光二极管。该器件的整体厚度为4μm。晶体管的通道电流根据生物标志物浓度而变化,从而改变发光二极管的辐照度以实现生物标志物监测。我们将该设备与弹性电池电路结合起来,打造出一款可穿戴贴片。我们还表明该系统可用于近红外图像分析。

更新日期:2024-09-03
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