Enzymatic Synthesis of Disialyllacto-N-Tetraose (DSLNT) and Related Human Milk Oligosaccharides Reveals Broad Siglec Recognition of the Atypical Neu5Acα2-6GlcNAc Motif,Angewandte Chemie International Edition

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Enzymatic Synthesis of Disialyllacto-N-Tetraose (DSLNT) and Related Human Milk Oligosaccharides Reveals Broad Siglec Recognition of the Atypical Neu5Acα2-6GlcNAc Motif
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2024-09-02 , DOI: 10.1002/anie.202411863
Shumin Bao ₁ , Tangliang Shen ₁ , MohammadHossein Shabahang ₁ , Guitao Bai ₁ , Lei Li ₂

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Taking advantage of the efficiency and substrate promiscuity of human ST6GalNAc enzymes along with a panel of enzyme modules, a library of human milk oligosaccharides (HMO) containing an atypical Neu5Aca2-6GlcNAc linkage including disialyllacto-N-tetraose (DSLNT) was synthesized for the first time. Glycan microarray assays revealed broad yet distinct recognition by Siglecs of the atypical Neu5Aca2-6GlcNAc motif.

中文翻译：

二唾液酸乳-N-四糖（DSLNT）和相关母乳低聚糖的酶促合成揭示了对非典型 Neu5Acα2-6GlcNAc 基序的广泛识别

利用人 ST6GalNAc 酶的效率和底物混杂性以及一组酶模块，首次合成了含有非典型 Neu5Aca2-6GlcNAc 键（包括二唾液酸乳-N-四糖（DSLNT））的人乳低聚糖库。聚糖微阵列分析显示 Siglecs 对非典型 Neu5Aca2-6GlcNAc 基序的广泛而独特的识别。

更新日期：2024-09-02

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