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Incidence and Risk Factors for Invasive Fungal Infections in Patients Initiating Tumor Necrosis Factor–Alpha Inhibitors for Inflammatory Bowel Disease and Rheumatoid Arthritis
Clinical Infectious Diseases ( IF 8.2 ) Pub Date : 2024-08-31 , DOI: 10.1093/cid/ciae444
Ian Hennessee 1, 2 , Kaitlin Benedict 1 , Nathan C Bahr 3 , Shari R Lipner 4 , Jeremy A W Gold 1
Affiliation  

In a commercial claims database analysis, <0.5% of patients with inflammatory bowel disease or rheumatoid arthritis developed an invasive fungal infection (IFI) within 1 year of initiating tumor necrosis factor–alpha therapy. Histoplasmosis was the most common IFI type. Overall IFI incidence varied based on region, underlying conditions, and use of certain immunosuppressive medications.

中文翻译:


开始使用肿瘤坏死因子-α 抑制剂治疗炎症性肠病和类风湿性关节炎的患者侵袭性真菌感染的发生率和危险因素



在商业索赔数据库分析中,<0.5% 的炎症性肠病或类风湿性关节炎患者在开始肿瘤坏死因子-α 治疗后 1 年内发生侵袭性真菌感染 (IFI)。组织胞浆菌病是最常见的 IFI 类型。总体 IFI 发生率因地区、潜在疾病和某些免疫抑制药物的使用而异。
更新日期:2024-08-31
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