Causal Association Between Sedentary Behaviors and Health Outcomes: A Systematic Review and Meta-Analysis of Mendelian Randomization Studies,Sports Medicine

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Causal Association Between Sedentary Behaviors and Health Outcomes: A Systematic Review and Meta-Analysis of Mendelian Randomization Studies
Sports Medicine ( IF 9.3 ) Pub Date : 2024-09-02 , DOI: 10.1007/s40279-024-02090-5
Ying Gao ₁ , Qingyang Li ₁ , Luyao Yang ₁ , Hanhua Zhao ₁ , Di Wang ₁ , Arto J Pesola ₂

Affiliation

Background

Different types of sedentary behavior are associated with several health outcomes, but the causality of these associations remains unclear.

Objectives

To conduct a systematic review and meta-analysis of Mendelian randomization (MR) studies investigating the associations between sedentary behaviors and health outcomes.

Methods

A systematic search on PubMed, Embase, Web of Science, Scopus, and PsycINFO up to August 2023 was conducted to identify eligible MR studies. We selected studies that assessed associations of genetically determined sedentary behaviors and health outcomes. A meta-analysis was conducted to examine the causal associations when two or more MR studies were available. We graded the evidence level of each MR association based on the results of the main method and sensitivity analyses in MR studies.

Results

A total of 31 studies with 168 MR associations between six types of sedentary behavior and 47 health outcomes were included. Results from meta-analyses suggested a total of 47 significant causal associations between sedentary behaviors and health outcomes. Notably, more leisure TV watching is robustly correlated with increased risks of myocardial infarction, coronary artery disease, all-cause ischemic stroke, and type 2 diabetes. Conversely, robust inverse associations were observed between leisure computer use and risks of rheumatoid arthritis, Alzheimer’s disease, and gastroesophageal reflux disease.

Conclusion

These findings suggest that different types of sedentary behavior have distinct causal effects on health outcomes. Therefore, interventions should focus not only on reducing sedentary time but also on promoting healthier types of sedentary behavior.

PROSPERO Registration

CRD42023453828.

中文翻译：

久坐行为与健康结果之间的因果关系：孟德尔随机研究的系统回顾和荟萃分析

背景

不同类型的久坐行为与多种健康结果相关，但这些关联的因果关系仍不清楚。

目标

对调查久坐行为与健康结果之间关联的孟德尔随机化 (MR) 研究进行系统回顾和荟萃分析。

方法

截至 2023 年 8 月，我们对 PubMed、Embase、Web of Science、Scopus 和 PsycINFO 进行了系统检索，以确定符合条件的 MR 研究。我们选择了评估遗传决定的久坐行为与健康结果之间关联的研究。当有两项或多项 MR 研究可用时，进行荟萃分析以检查因果关系。我们根据 MR 研究中主要方法和敏感性分析的结果对每个 MR 关联的证据级别进行分级。

结果

总共纳入了 31 项研究，涉及六种久坐行为与 47 种健康结果之间的 168 种 MR 关联。荟萃分析结果表明，久坐行为与健康结果之间总共存在 47 个显着因果关系。值得注意的是，更多的休闲电视观看与心肌梗塞、冠状动脉疾病、全因缺血性中风和 2 型糖尿病的风险增加密切相关。相反，在休闲计算机使用与类风湿性关节炎、阿尔茨海默病和胃食管反流病的风险之间观察到强烈的负相关关系。