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Discovery of novel BfmR inhibitors restoring carbapenem susceptibility against carbapenem-resistant Acinetobacter baumannii by structure-based virtual screening and biological evaluation
Emerging Microbes & Infections ( IF 8.4 ) Pub Date : 2024-09-09 , DOI: 10.1080/22221751.2024.2396877 Yue Yao 1, 2, 3 , Tailong Lei 1, 2, 3, 4 , Junbo Gao 4 , Qingye Xu 1, 2, 3 , Lei Xu 5 , Buhui Zhao 6, 7 , Shangshang Qin 6, 7 , Yunsong Yu 1, 2, 3 , Xiaoting Hua 1, 2, 3
Emerging Microbes & Infections ( IF 8.4 ) Pub Date : 2024-09-09 , DOI: 10.1080/22221751.2024.2396877 Yue Yao 1, 2, 3 , Tailong Lei 1, 2, 3, 4 , Junbo Gao 4 , Qingye Xu 1, 2, 3 , Lei Xu 5 , Buhui Zhao 6, 7 , Shangshang Qin 6, 7 , Yunsong Yu 1, 2, 3 , Xiaoting Hua 1, 2, 3
Affiliation
The emergence and spread of Acinetobacter baumannii pose a severe threat to public health, highlighting the urgent need for the next generation of therapeutics due to its increasing resistance to e...
中文翻译:
通过基于结构的虚拟筛选和生物学评价发现新型 BfmR 抑制剂,可恢复碳青霉烯类抗生素对碳青霉烯类耐药鲍曼不动杆菌的敏感性
鲍曼不动杆菌的出现和传播对公众健康构成严重威胁,由于其对电子的抵抗力不断增强,因此迫切需要下一代治疗方法。
更新日期:2024-09-09
中文翻译:
通过基于结构的虚拟筛选和生物学评价发现新型 BfmR 抑制剂,可恢复碳青霉烯类抗生素对碳青霉烯类耐药鲍曼不动杆菌的敏感性
鲍曼不动杆菌的出现和传播对公众健康构成严重威胁,由于其对电子的抵抗力不断增强,因此迫切需要下一代治疗方法。