Vaginal childbirth is a key risk factor for pelvic floor muscle injury and dysfunction, and subsequent pelvic floor disorders. Multiparity further exacerbates these risks. Using the rat model, validated for the studies of the human pelvic floor muscles, we have previously identified that a single simulated birth injury results in pelvic floor muscle atrophy and fibrosis.

中文翻译：

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在临床前大鼠模型中，反复的产伤导致长期盆底肌功能障碍


阴道分娩是盆底肌肉损伤和功能障碍以及随后的盆底疾病的关键危险因素。胎次进一步加剧了这些风险。使用经过人类盆底肌肉研究验证的大鼠模型，我们之前已经确定单次模拟出生损伤会导致盆底肌肉萎缩和纤维化。