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Illuminating GPCR trafficking
Nature Chemical Biology ( IF 12.9 ) Pub Date : 2024-09-02 , DOI: 10.1038/s41589-024-01699-x
Michelle L Halls 1
Affiliation  

A method to study G-protein-coupled receptor (GPCR) trafficking has been developed using engineered APEX2 and CRISPR interference screening. The innovative approach reveals a network of proteins coordinated by DNAJC13 that control efficient GPCR sorting into degradative or recycling pathways.

中文翻译:


阐明 GPCR 贩运



使用工程 APEX2 和 CRISPR 干扰筛选开发了一种研究 G 蛋白偶联受体 (GPCR) 运输的方法。这种创新方法揭示了由 DNAJC13 协调的蛋白质网络,该网络控制有效的 GPCR 分类到降解或回收途径。
更新日期:2024-09-02
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