Developing materials for “Nano-vehicles” with clinically approved drugs encapsulated is envisaged to enhance drug therapeutic effects and reduce the adverse effects. However, design and preparation of the biomaterials that are porous, nontoxic, soluble, and stable in physiological solutions and could be easily functionalized for effective drug deliveries are still challenging. Here, we report an original and simple thermal substitution method to fabricate perfectly water-soluble and porous boron nitride (BN) materials featuring unprecedentedly high hydroxylation degrees. These hydroxylated BNs are biocompatible and can effectively load anticancer drugs (e.g., doxorubicin, DOX) up to contents three times exceeding their own weight. The same or even fewer drugs that are loaded on such BN carriers exhibit much higher potency for reducing the viability of LNCaP cancer cells than free drugs.

中文翻译：

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具有高度水溶性，多孔性和生物相容性的氮化硼，可用于抗癌药物输送

设想开发具有封装的临床认可药物的“纳米车辆”材料，以增强药物治疗效果并减少不良影响。然而，设计和制备在生理溶液中是多孔的，无毒的，可溶的和稳定的并且可以容易地功能化以进行有效药物递送的生物材料仍然具有挑战性。在这里，我们报告了一种原始且简单的热取代方法，以制造具有前所未有的高羟基化度的水溶性和多孔氮化硼（BN）完美材料。这些羟基化的BN具有生物相容性，可以有效负载抗癌药物（例如，阿霉素（DOX）含量超过其自身重量的三倍。与游离药物相比，装载在此类BN载体上的相同或更少的药物表现出更高的降低LNCaP癌细胞生存力的能力。