Antidepressants used by patients with bipolar disorder have been associated with destabilization with an increase in mania, depression, and cycling. The most commonly proposed mechanism, that antidepressants ‘overshoot’ their antidepressant effect to create a manic or mixed state, is unlikely since antidepressants have actually been found to be ineffective in treating bipolar depression. Beginning with known bipolar-specific pathophysiologic abnormalities provides the greatest likelihood of insight.

中文翻译：

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概念文章：抗抑郁药引起的双相情感障碍由血清素 3 受体 (5HT3) 介导的不稳定


双相情感障碍患者使用的抗抑郁药与不稳定、躁狂、抑郁和骑自行车的增加有关。最常提出的机制是抗抑郁药“过度”其抗抑郁作用而产生躁狂或混合状态，这种机制不太可能，因为实际上已经发现抗抑郁药对治疗双相抑郁症无效。从已知的双相情感障碍特异性病理生理异常开始提供最大的洞察力。