Managing menopause symptoms is challenging for women unable or unwilling to take hormone therapy. All nonhormone options thus far have shown less overall efficacy compared with hormone therapy and significant adverse events that limit their use. New science has identified the source of vasomotor symptoms, achieving relief of these bothersome symptoms by directly targeting the neurokinin 3 receptor and its related pathways. This Practice Pearl reviews the clinical data available on neurokinin receptor antagonists.

中文翻译：

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神经激肽受体拮抗剂作为血管舒缩症状的潜在非激素治疗方法。


对于无法或不愿意接受激素治疗的女性来说，控制更年期症状具有挑战性。迄今为止，与激素疗法相比，所有非激素疗法的总体疗效都较差，并且出现了限制其使用的重大不良事件。新科学已经确定了血管舒​​缩症状的根源，通过直接靶向神经激肽 3 受体及其相关途径来缓解这些令人烦恼的症状。本实践珍珠回顾了神经激肽受体拮抗剂的可用临床数据。