OBJECTIVE Human papillomavirus (HPV) infection and menopause entail a considerable impairment in health-related quality of life (HRQoL). The objective of the present study was to analyze the impact of the menopause status on HRQoL in women with HPV infection. METHODS A cross-sectional, nationwide, multicenter sample of women with HPV infection was conducted throughout clinics of gynecology representative of the Spanish population with regard to age, geographic density, and autonomous regions. Demographic and clinical characteristics and the specific HPV-QoL questionnaire score with its domains were compared according to reproductive status: premenopausal and peri-/postmenopausal. Correlation with other validated patient-reported outcomes measurements was also tested, including General Health Questionnaire-12 (GHQ-12), Female Sexual Function Index (FSFI), and Hospital Anxiety and Depression Scale (HADS). RESULTS A sample of 1,016 noninstitutionalized women, aged 18-80 y, was recorded, 191 (18.8%) peri-/postmenopausal and 825 (81.2%) premenopausal. Total HPV-QoL scoring was significantly lower in peri-/postmenopausal (38.8, 95% CI [35.2-42.4]) compared to premenopausal (46.4, 95% CI [45.0-47.8]) women, and also in every domain of the scale (P < 0.05), except in social well-being and health domains, with a small effect size of 0.39. In women with sexual dysfunction according to FSFI, adjusted total scoring and domains sexuality, general well-being, and psychological well-being scored significantly higher in premenopause women (P < 0.01), although the magnitude of differences were of small to moderate size. CONCLUSIONS HRQoL was impaired during menopause in women with HPV infection according to HPV-QoL questionnaire. The sexuality domain was the most differentiating dimension between these populations.

中文翻译：

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患有人乳头瘤病毒的成年女性的更年期：与健康相关的生活质量和决定因素。


目的 人乳头瘤病毒 (HPV) 感染和更年期会对健康相关的生活质量 (HRQoL) 造成相当大的损害。本研究的目的是分析绝经状态对 HPV 感染女性 HRQoL 的影响。方法 在各个妇科诊所对 HPV 感染女性进行了横断面、全国性、多中心的抽样调查，这些样本代表了西班牙人口的年龄、地理密度和自治区。根据绝经前和绝经前后/绝经后的生殖状态，对人口统计学和临床​​特征以及特定 HPV-QoL 问卷评分及其领域进行比较。还测试了与其他经过验证的患者报告结果测量的相关性，包括一般健康问卷 12 (GHQ-12)、女性性功能指数 (FSFI) 和医院焦虑和抑郁量表 (HADS)。结果 记录了 1,016 名年龄在 18-80 岁的非收容妇女样本，其中 191 名 (18.8%) 为围绝经期/绝经后妇女，825 名 (81.2%) 为绝经前妇女。与绝经前女性（46.4，95% CI [45.0-47.8]）相比，围绝经期/绝经后女性的 HPV-QoL 总评分（38.8，95% CI [35.2-42.4]）显着较低，在量表的每个领域也是如此(P < 0.05)，社会福祉和健康领域除外，效应大小较小，为 0.39。根据 FSFI，在患有性功能障碍的女性中，调整后的总分以及性行为、总体幸福感和心理健康方面的得分在绝经前女性中显着较高 (P < 0.01)，尽管差异程度为小到中等。结论 根据 HPV-QoL 问卷，HPV 感染女性绝经期间 HRQoL 受损。 性领域是这些人群之间最具差异性的维度。