ion and/or trafficking are key to sustain osmosis in multiple tissues. Here, we review the convergent evidence demonstrating that aquaporin-1 (AQP1) facilitates water transport across endothelial cells in the peritoneal membrane, a key process for peritoneal dialysis—the leading modality of home-based dialysis therapy for patients with kidney failure. Genetic and pharmacologic studies in mouse and cell models indicated that AQP1 plays a critical role in crystalloid osmosis, with clinically relevant effects on water transport and risk of death and technique failure for patients on dialysis. By contrast, AQP1 plays no role in colloid osmosis. These studies substantiate potential strategies to improve free water transport and ultrafiltration in patients treated by peritoneal dialysis....

中文翻译：

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水通道蛋白-1 和渗透：腹膜透析的生理学到精确度


离子和/或运输是维持多个组织渗透的关键。在这里，我们回顾了表明水通道蛋白 1 （AQP1） 促进水在腹膜中跨内皮细胞的运输，这是腹膜透析的关键过程——肾功能衰竭患者家庭透析治疗的主要方式。小鼠和细胞模型中的遗传学和药理学研究表明，AQP1 在晶体渗透中起关键作用，对透析患者的水运输和死亡风险和技术失败具有临床相关影响。相比之下，AQP1 在胶体渗透中不起任何作用。这些研究证实了改善腹膜透析治疗患者自由水转运和超滤的潜在策略。