The emergence of multidrug-resistant poses a grave threat to global public health, necessitating urgent strategies for vaccine development. In this context, computational tools have emerged as indispensable assets, offering unprecedented insights into klebsiellal biology and facilitating the design of effective vaccines. Here, a review of the application of computational methods in the development of vaccines is presented, elucidating the transformative impact of in silico approaches. Through a systematic exploration of bioinformatics, structural biology, and immunoinformatics techniques, the complex landscape of pathogenesis and antigenicity was unravelled. Key insights into virulence factors, antigen discovery, and immune response mechanisms are discussed, highlighting the pivotal role of computational tools in accelerating vaccine development efforts. Advancements in epitope prediction, antigen selection, and vaccine design optimisation are examined, highlighting the potential of in silico approaches to update vaccine development pipelines. Furthermore, challenges and future directions in leveraging computational tools to combat are discussed, emphasizing the importance of multidisciplinary collaboration and data integration. This review provides a comprehensive overview of the current state of computational contributions to vaccine development, offering insights into innovative strategies for addressing this urgent global health challenge.

中文翻译：

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肺炎克雷伯菌疫苗设计中的计算策略：驾驭计算机见解的景观。


多重耐药性的出现对全球公共卫生构成严重威胁，迫切需要制定疫苗开发策略。在这种背景下，计算工具已成为不可或缺的资产，为克雷伯氏菌生物学提供了前所未有的见解，并促进了有效疫苗的设计。在这里，对计算方法在疫苗开发中的应用进行了回顾，阐明了计算机方法的变革性影响。通过对生物信息学、结构生物学和免疫信息学技术的系统探索，阐明了发病机制和抗原性的复杂情况。讨论了毒力因子、抗原发现和免疫反应机制的关键见解，强调了计算工具在加速疫苗开发工作中的关键作用。研究了表位预测、抗原选择和疫苗设计优化方面的进展，突出了计算机方法更新疫苗开发流程的潜力。此外，还讨论了利用计算工具进行战斗的挑战和未来方向，强调了多学科协作和数据集成的重要性。这篇综述全面概述了计算对疫苗开发的贡献的现状，为解决这一紧迫的全球健康挑战的创新策略提供了见解。