Endo-periodontal lesions (EPLs) involve both the periodontium and pulp tissue and have complicated etiologies and pathogenic mechanisms, including unique anatomical and microbiological characteristics and multiple contributing factors. This etiological complexity leads to difficulties in determining patient prognosis, posing great challenges in clinical practice. Furthermore, EPL-affected teeth require multidisciplinary therapy, including periodontal therapy, endodontic therapy and others, but there is still much debate about the appropriate timing of periodontal therapy and root canal therapy. By compiling the most recent findings on the etiology, pathogenesis, clinical characteristics, diagnosis, therapy, and prognosis of EPL-affected teeth, this consensus sought to support clinicians in making the best possible treatment decisions based on both biological and clinical evidence.

牙周内病变（EPL）涉及牙周组织和牙髓组织，具有复杂的病因和致病机制，包括独特的解剖和微生物学特征以及多种影响因素。这种病因学的复杂性导致了确定患者预后的困难，给临床实践带来了巨大的挑战。此外，EPL影响的牙齿需要多学科治疗，包括牙周治疗、牙髓治疗等，但对于牙周治疗和根管治疗的适当时机仍存在很多争议。通过汇编有关 EPL 影响牙齿的病因、发病机制、临床特征、诊断、治疗和预后的最新发现，该共识旨在支持临床医生根据生物学和临床证据做出最佳的治疗决策。