Electrochemical-modulated surface-enhanced Raman scattering (EC-SERS) integrates the benefits of SERS with electrochemical techniques. By controlling the electrode potential, Raman spectroscopy allows for the analysis of molecules with enhanced sensitivity and selectivity. With its large volume and high sample consumption, the traditional three-electrode electrochemical cell constrains the widespread adoption of EC-SERS. This study developed a versatile EC-SERS platform based on Ag nanowires-modified screen-printed electrode (AgNWs-SPE). Taking advantage of the dual functionality of AgNWs-SPE, this platform facilitates the successful in situ collection and sensitive detection of charged molecules. Experimental findings and theoretical calculations validate the platform's high sensitivity and selectivity mainly regulated by the applied potential, providing a universal approach for the highly sensitive and accurate detection of charged molecules.

中文翻译：

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用于灵敏检测带电分子的通用电化学调制表面增强拉曼散射平台


电化学调制表面增强拉曼散射 (EC-SERS) 将 SERS 的优点与电化学技术相结合。通过控制电极电位，拉曼光谱可以提高分子分析的灵敏度和选择性。传统三电极电化学池体积大、样品消耗量大，限制了EC-SERS的广泛应用。本研究开发了一种基于银纳米线改性丝网印刷电极（AgNWs-SPE）的多功能 EC-SERS 平台。该平台利用 AgNWs-SPE 的双重功能，促进带电分子的成功原位收集和灵敏检测。实验结果和理论计算验证了该平台的高灵敏度和选择性主要由施加的电位调节，为带电分子的高灵敏度和准确检测提供了通用方法。