Fever is one of the main pathophysiological reactions that occurs during the acute phase of various diseases. Excessive body temperature can lead to various adverse consequences such as brain tissue damage and abnormal immune responses. Phillyrin (Phr) is the main active ingredient in Forsythia suspensa (Thunb.) Vahl (Lian Qiao) and has antipyretic effects; however, its antipyretic mechanism of action remains unclear.

中文翻译：

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Phillyrin 及其代谢物通过靶向 GAPDH、MDH2 和 IDH2 的 NAD+ 结合域发挥解热作用


发热是各种疾病急性期发生的主要病理生理反应之一。体温过高会导致各种不良后果，例如脑组织损伤和免疫反应异常。Phillyrin （Phr） 是连翘 （Thunb.） 的主要活性成分。Vahl （连乔） 并具有解热作用;然而，其解热作用机制仍不清楚。