Fever is one of the main pathophysiological reactions that occurs during the acute phase of various diseases. Excessive body temperature can lead to various adverse consequences such as brain tissue damage and abnormal immune responses. Phillyrin (Phr) is the main active ingredient in Forsythia suspensa (Thunb.) Vahl (Lian Qiao) and has antipyretic effects; however, its antipyretic mechanism of action remains unclear.

中文翻译：

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Phillyrin 及其代谢物通过靶向 GAPDH、MDH2 和 IDH2 的 NAD+ 结合域发挥解热作用


发热是多种疾病急性期发生的主要病理生理反应之一。体温过高会导致脑组织损伤、免疫反应异常等多种不良后果。连翘苷（Phr）是连翘的主要活性成分，具有解热作用；然而，其解热作用机制仍不清楚。