In this work hybrid magnetite (Fe3O4)/poly(3,4-ethylenedioxythiophene) (PEDOT) core-shell particles are used to produce electro-responsive self-standing polycaprolactone (PCL) membranes with many potential applications. For this purpose, Fe3O4/PEDOT core-shell particles with different magnetite contents are prepared by combining chemical precipitation and emulsion polymerization. After chemical, morphological and physical characterization, the electrochemical response of the hybrid particles is analyzed and compared with that of PEDOT nanoparticles. In all cases, Fe3O4/PEDOT core-shell particles are more electroactive than PEDOT particles, with the electrochemical response of the former increasing with the content of magnetite. Composite membranes were prepared by spin-coating a mixture of polycaprolactone (PCL) and Fe3O4/PEDOT particles. The resulting Fe3O4/PEDOT-PCL membranes, which maintained the magnetic behavior, were transformed into electro-responsive by incorporating a PEDOT surface layer through anodic polymerization, which was possible thanks to the role of Fe3O4/PEDOT particles as polymerization nuclei. One of the potential applications of self-supported electro-responsive Fe3O4/PEDOT-PCL/PEDOT membranes was illustrated through a proof-of-concept. Specifically, a wide-spectrum antibiotic, chloramphenicol, was loaded into the membranes during the anodic polymerization step promoted by the hybrid Fe3O4/PEDOT particles and, subsequently, completely released by electrical stimulation. Overall, Fe3O4/PEDOT core-shell particles allowed us to obtain self-standing membranes with electric and magnetic properties, as promising candidates for many technological applications.

中文翻译：

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磁铁矿/聚(3,4-乙撑二氧噻吩)核壳粒子制备的电活性自支撑聚酯膜


在这项工作中，混合磁铁矿（Fe3O4）/聚（3,4-乙撑二氧噻吩）（PEDOT）核壳颗粒用于生产具有许多潜在应用的电响应自支撑聚己内酯（PCL）膜。为此，通过化学沉淀和乳液聚合相结合的方法制备了不同磁铁矿含量的Fe3O4/PEDOT核壳颗粒。经过化学、形态和物理表征后，对杂化颗粒的电化学响应进行了分析，并与 PEDOT 纳米颗粒的电化学响应进行了比较。在所有情况下，Fe3O4/PEDOT 核壳颗粒都比 PEDOT 颗粒更具电活性，前者的电化学响应随着磁铁矿含量的增加而增加。通过旋涂聚己内酯 (PCL) 和 Fe3O4/PEDOT 颗粒的混合物制备复合膜。所得的 Fe3O4/PEDOT-PCL 膜保持了磁性行为，通过阳极聚合并入 PEDOT 表面层，将其转变为电响应膜，这得益于 Fe3O4/PEDOT 颗粒作为聚合核的作用。通过概念验证说明了自支撑电响应 Fe3O4/PEDOT-PCL/PEDOT 膜的潜在应用之一。具体来说，在混合 Fe3O4/PEDOT 颗粒促进的阳极聚合步骤中，将广谱抗生素氯霉素加载到膜中，随后通过电刺激完全释放。总体而言，Fe3O4/PEDOT 核壳颗粒使我们能够获得具有电学和磁学特性的自支撑膜，作为许多技术应用的有希望的候选者。