The increasing prevalence of severe bone diseases, such as osteoporosis and critical bone defects, necessitates the development of more effective bone substitutes. This study addresses this need by investigating 3D-printed bone scaffolds composed of sodium alginate and tricalcium phosphate, enhanced with three distinct types of hydroxyapatite (HA): bovine-derived HA, commercially available HA, and HA enriched with probiotic bacteria. We aim to evaluate the performance of these scaffolds in terms of mechanical strength, biocompatibility, and their ability to support bone regeneration.

中文翻译：

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采用海藻酸钠/磷酸三钙/益生菌羟基磷灰石的先进 3D 打印骨支架：增强骨组织工程的机械和生物相容性


骨质疏松症和严重骨缺陷等严重骨病的患病率不断增加，需要开发更有效的骨替代品。本研究通过研究由海藻酸钠和磷酸三钙组成的 3D 打印骨支架来满足这一需求，并用三种不同类型的羟基磷灰石 (HA) 进行增强：牛源性 HA、市售 HA 和富含益生菌的 HA。我们的目标是评估这些支架在机械强度、生物相容性及其支持骨再生的能力方面的性能。