Bridging the gap: Multi-omics profiling of brain tissue in Alzheimer's disease and older controls in multi-ethnic populations,Alzheimer's & Dementia

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Bridging the gap: Multi-omics profiling of brain tissue in Alzheimer's disease and older controls in multi-ethnic populations
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2024-08-30 , DOI: 10.1002/alz.14208
Joseph S Reddy ₁ , Laura Heath ₂ , Abby Vander Linden ₂ , Mariet Allen ₁ , Katia de Paiva Lopes ₃ , Fatemeh Seifar ₄ , Erming Wang _{5,

6} , Yiyi Ma ₇ , William L Poehlman ₂ , Zachary S Quicksall ₁ , Alexi Runnels ₈ , Yanling Wang ₃ , Duc M Duong ₄ , Luming Yin ₄ , Kaiming Xu ₄ , Erica S Modeste ₄ , Anantharaman Shantaraman ₄ , Eric B Dammer ₄ , Lingyan Ping ₄ , Stephanie R Oatman ₁ , Jo Scanlan ₂ , Charlotte Ho ₁ , Minerva M Carrasquillo ₁ , Merve Atik ₁ , Geovanna Yepez ₁ , Adriana O Mitchell ₁ , Thuy T Nguyen ₁ , Xianfeng Chen ₁ , David X Marquez _{3,

9} , Hasini Reddy ₇ , Harrison Xiao ₇ , Sudha Seshadri ₁₀ , Richard Mayeux ₇ , Stefan Prokop ₁₁ , Edward B Lee ₁₂ , Geidy E Serrano ₁₃ , Thomas G Beach ₁₃ , Andrew F Teich ₇ , Varham Haroutunian ₅ , Edward J Fox ₄ , Marla Gearing ₄ , Aliza Wingo ₄ , Thomas Wingo ₄ , James J Lah ₄ , Allan I Levey ₄ , Dennis W Dickson ₁ , Lisa L Barnes ₃ , Philip De Jager ₇ , Bin Zhang _{5,

6} , David Bennett ₃ , Nicholas T Seyfried ₄ , Anna K Greenwood ₂ , Nilüfer Ertekin-Taner ₁

Affiliation

Mayo Clinic Florida, Jacksonville, Florida, USA.
Sage Bionetworks, Seattle, Washington, USA.
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Emory University School of Medicine, Atlanta, Georgia, USA.
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Columbia University Irving Medical Center, New York, New York, USA.
New York Genome Center, New York, New York, USA.
University of Illinois Chicago, Chicago, Illinois, USA.
The Glen Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas, San Antonio, Texas, USA.
University of Florida, Gainesville, Florida, USA.
Center for Neurodegenerative Disease Brain Bank at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Banner Sun Health Research Institute, Sun City, Arizona, USA.

Multi-omics studies in Alzheimer's disease (AD) revealed many potential disease pathways and therapeutic targets. Despite their promise of precision medicine, these studies lacked Black Americans (BA) and Latin Americans (LA), who are disproportionately affected by AD.

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