Dynamic Chemistry of DNA-Based Nanoassemblies in Living Cells,Accounts of Chemical Research

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Dynamic Chemistry of DNA-Based Nanoassemblies in Living Cells
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2024-08-30 , DOI: 10.1021/acs.accounts.4c00301
Nachuan Song _{1,

2} , Hongjin Li ₂ , Chi Yao ₂ , Dayong Yang _{1,

2}

Affiliation

In recent years, the controlled assembly/disassembly of exogenous chemical components inside cells has become an emerging approach to regulating cell functions. However, the construction of dynamic material chemistry systems in living cells always remains highly challenging due to the complicated intracellular microenvironment. Nucleic acid is a category of biological components that can achieve efficient molecular assembly via specific base-pairing and perform biological functions in the intracellular microenvironment. Deoxyribonucleic acid (DNA) molecules exhibit the superior performance of intracellular assembly, including sequence programmability, molecule recognition ability, and nanostructure predictability, as well as the unique biological functions that traditional synthetic polymers do not carry, showing great superiority in the construction of dynamic material chemistry systems. Moreover, the technologies of DNA synthesis are relatively mature, and the conjugation of DNA with functional small molecules can be achieved through established chemical synthesis methods, facilitating the construction of DNA-based dynamic materials with more functions. In addition, a few specific DNA molecules have been proven to show responsiveness toward different stimuli, functioning as dynamic modules.

中文翻译：

活细胞中基于 DNA 的纳米组装体的动态化学

近年来，细胞内外源性化学成分的受控组装/拆解已成为一种调节细胞功能的新兴方法。然而，由于复杂的细胞内微环境，活细胞中动态材料化学系统的构建始终极具挑战性。核酸是一类生物成分，可以通过特定的碱基配对实现高效的分子组装，并在细胞内微环境中执行生物学功能。脱氧核糖核酸（DNA）分子表现出卓越的细胞内组装性能，包括序列可编程性、分子识别能力和纳米结构可预测性，以及传统合成聚合物所不具备的独特生物学功能，在动态材料化学系统的构建中显示出极大的优越性。而且，DNA 合成技术相对成熟，通过建立的化学合成方法可以实现 DNA 与功能性小分子的偶联，有利于构建功能更强的基于 DNA 的动态材料。此外，一些特定的 DNA 分子已被证明对不同的刺激表现出响应性，起到动态模块的作用。

更新日期：2024-08-30

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