The Function and Mechanism of Laminaripentaose Prepared from Curdlan for the Amelioration of the Cognitive Dysfunctions in Obese Mice,Journal of Agricultural and Food Chemistry

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The Function and Mechanism of Laminaripentaose Prepared from Curdlan for the Amelioration of the Cognitive Dysfunctions in Obese Mice
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2024-08-31 , DOI: 10.1021/acs.jafc.4c05163
Yuncong Xu ₁ , Yanxiao Li ₂ , Qiaojuan Yan ₂ , Xiangzhao Mao ₃ , Shaoqing Yang ₁ , Zhengqiang Jiang _{1,

4}

Affiliation

Functional oligosaccharides induce specific alterations in gut microbiota, potentially providing physiological benefits. However, the effects of laminaripentaose (LPA) on metabolic syndrome and the mechanism underlying it have not been intensively investigated yet. This study aimed to determine the effects of LPA on obesity and obesity-induced cognition impairment in mice. C57BL/6N mice fed with a high-fat diet received an LPA treatment for 12 weeks. An antibiotic intervention was further applied to evaluate the effects of the gut microbiota on cognitive functions. LPA treatment (500 mg/kg) reduced the weight gain by 32.4%. Furthermore, LPA improved memory functions and reduced hippocampal insulin resistance and neuronal injury. LPA markedly reduced systemic low-grade inflammation and intestinal barrier injury. Moreover, LPA increased gut beneficial bacteria, and Butyricimonas and Bifidobacterium were increased by 94.0 and 422.7%, respectively, accompanied by increased fecal short-chain fatty acids. Interestingly, antibiotic cocktail treatment abrogated the beneficial effects of LPA on cognition, which further suggests that LPA may attenuate obesity-induced cognition impairment via the gut-brain axis. Our findings provide the first evidence for the potential of dietary LPA to prevent obesity and obesity-associated complications.

中文翻译：

可得然胶制备的昆布五糖改善肥胖小鼠认知功能的作用及机制

功能性低聚糖可诱导肠道微生物群的特定改变，从而可能提供生理益处。然而，昆布五糖（LPA）对代谢综合征的影响及其潜在机制尚未得到深入研究。本研究旨在确定 LPA 对小鼠肥胖和肥胖引起的认知障碍的影响。高脂肪饮食喂养的 C57BL/6N 小鼠接受 LPA 治疗 12 周。进一步应用抗生素干预来评估肠道微生物群对认知功能的影响。 LPA 处理（500 毫克/千克）使体重增加减少了 32.4%。此外，LPA 可改善记忆功能并减少海马胰岛素抵抗和神经元损伤。 LPA 显着减少全身低度炎症和肠道屏障损伤。此外，LPA 增加了肠道有益细菌，丁酸单胞菌和双歧杆菌分别增加了 94.0% 和 422.7%，同时粪便短链脂肪酸也增加了。有趣的是，抗生素鸡尾酒治疗消除了 LPA 对认知的有益作用，这进一步表明 LPA 可能通过肠-脑轴减轻肥胖引起的认知障碍。我们的研究结果为膳食 LPA 预防肥胖和肥胖相关并发症的潜力提供了第一个证据。

更新日期：2024-09-01

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