Clostridioides difficile is a spore-forming, toxin-producing, anaerobic bacterium that infects the human gastrointestinal tract, causing diarrhea and life-threatening colitis. Clostridioides difficile epidemiology continues to evolve, and it is recognized as a major community-associated (CA) pathogen in addition to its established role in causing healthcare-associated (HA) infection. While current surveillance and prevention measures mainly focus on healthcare-associated C. difficile infections (HA-CDI), much less is known about the factors that drive CA-CDI. This review highlights the potential contribution of reservoirs, including asymptomatic carriers, to CA C. difficile transmission. The reservoirs discussed in this review provide potential avenues for research to better understand and reduce CA transmission of C. difficile.

中文翻译：

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社区相关性艰难梭菌感染的多种来源和潜在宿主


艰难梭菌是一种形成孢子、产生毒素的厌氧细菌，可感染人体胃肠道，引起腹泻和危及生命的结肠炎。艰难梭菌流行病学不断发展，除了在引起医疗保健相关 （HA） 感染中的作用外，它还被认为是一种主要的社区相关 （CA） 病原体。虽然目前的监测和预防措施主要集中在医疗保健相关的艰难梭菌感染 （HA-CDI） 上，但对驱动 CA-CDI 的因素知之甚少。本综述强调了宿主（包括无症状携带者）对艰难梭菌传播的潜在贡献。本综述中讨论的储层为研究提供了潜在的途径，以更好地了解和减少艰难梭菌的 CA 传播。