We read with great interest the systematic review by Honap et al 1 and commend the authors for highlighting the elevated risk of colectomy in patients with acute severe UC. While there is ample knowledge about colectomy as a last resort treatment in UC,2 little is known about the colectomy risk in microscopic colitis (MC).3–6 As the incidence of MC has been on the rise over the past decades,7 with current incidence rates (IRs) rivalling those of UC and Crohn’s disease,8 knowledge on the risk of colectomy in patients with MC is warranted. Leveraging the nationwide Swedish ESPRESSO histopathology cohort,9 we estimated the risk of colectomy in patients with biopsy-verified MC (diagnosed 1990–2017) compared with matched reference individuals from the general population (matched by age, sex, county of residence and calendar year). Colectomy was defined as having a corresponding surgical procedure code indicating total colectomy recorded in the National Patient Register (online supplemental table S1).### Supplementary data [gutjnl-2024-333505supp001.pdf] Follow-up began on the date of MC diagnosis (any of the subtypes of collagenous colitis or lymphocytic colitis) and on the matching date for the reference individuals. Study participants were followed until 31 December 2021 for colectomy, death, emigration or a medical …

中文翻译：

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显微镜下结肠炎的结肠切除术：罕见适应症


我们饶有兴趣地阅读了 Honap 等人的系统综述 1，并赞扬作者强调急性重症 UC 患者结肠切除术风险升高。虽然人们对结肠切除术作为 UC 的最后手段治疗有足够的了解，2 但人们对显微镜下结肠炎 (MC) 的结肠切除术风险知之甚少。3-6 由于 MC 的发病率在过去几十年中一直在上升，7目前的发病率 (IR) 与 UC 和克罗恩病相当，8 有必要了解 MC 患者结肠切除术的风险。利用瑞典全国 ESPRESSO 组织病理学队列9，我们估计了活检证实的 MC 患者（1990-2017 年诊断）与来自一般人群的匹配参考个体（按年龄、性别、居住县和日历年进行匹配）相比的结肠切除术风险）。结肠切除术被定义为在国家患者登记册中记录有相应的手术程序代码，表明全结肠切除术（在线补充表 S1）。### 补充数据 [gutjnl-2024-333505supp001.pdf] 随访从 MC 诊断之日开始（胶原性结肠炎或淋巴细胞性结肠炎的任何亚型）以及参考个体的匹配日期。研究参与者接受随访直至 2021 年 12 月 31 日，了解结肠切除术、死亡、移民或医疗……