Exposure to atrazine, a common herbicide frequently used in dry crops such as corn, can have negative effects on the reproductive and endocrine systems, according to several studies. Resveratrol, a naturally occurring phytoalexin antioxidant, is recognized as an effective treatment for the prevention of aging and reproductive impairments. A study in Scientific Reports explores whether resveratrol can reverse reproductive damage caused by atrazine in male rats. Atrazine exposure decreased male fertility and serum testosterone levels in rats, but cotreatment with resveratrol restored testosterone levels. Additionally, while atrazine upregulated caspase 3 and iNOS levels, cotreatment with resveratrol downregulated these markers compared to the atrazine-only group. Cotreatment also attenuated testicular tissue alterations caused by atrazine. However, resveratrol treatment did not rescue sperm morphology damage. Although resveratrol-treated animals did not completely recover from all of atrazine’s deleterious effects, the study suggests that resveratrol is a potentially beneficial supplement for protecting the reproductive system from toxic effects.

Original reference: Hassanin, H.M., Kamal, A.A. & Ismail, O.I. Sci. Rep. 14, 17743 (2024)

几项研究表明，接触莠去津是一种常见的除草剂，常用于玉米等干旱作物，会对生殖和内分泌系统产生负面影响。白藜芦醇是一种天然存在的植物抗氧化剂，被认为是预防衰老和生殖障碍的有效治疗方法。 《科学报告》中的一项研究探讨了白藜芦醇是否可以逆转莠去津对雄性大鼠造成的生殖损伤。暴露于莠去津会降低大鼠的雄性生育能力和血清睾酮水平，但与白藜芦醇联合治疗可恢复睾酮水平。此外，虽然莠去津上调了 caspase 3 和 iNOS 水平，但与仅使用莠去津的组相比，与白藜芦醇联合治疗却下调了这些标记物。联合治疗还减轻了莠去津引起的睾丸组织改变。然而，白藜芦醇治疗并不能挽救精子形态损伤。尽管经过白藜芦醇治疗的动物并未完全从莠去津的所有有害影响中恢复，但该研究表明，白藜芦醇是一种潜在有益的补充剂，可保护生殖系统免受毒性影响。

原始参考文献： Hassanin, HM, Kamal, AA & Ismail, OI Sci。代表。 14、17743 (2024)