Organ development and maturation are complex processes requiring dynamic fluctuations and precise balance of a multitude of molecules, especially during adolescence. Understanding the regulatory mechanisms in various organs during life is especially important for clarifying fundamental biological questions such as aging diseases. A study in Nature Communications presents a multi-organ proteome atlas in C57BL/6JN male and female mice at three critical developmental stages, from infancy to adulthood. To investigate dynamic protein variation in mice's organs from infancy to adulthood, the team conducted a proteomic analysis on ten organs (brain, heart, lung, liver, kidney, spleen, stomach, intestine, muscle and skin) isolated at postnatal weeks 1, 4 and 8. This atlas of >11,000 proteins, showing 115 age-related protein groups, provides a useful resource for understanding the molecular mechanisms driving organ development and maturation.

Original reference: Wang, Q. et al. Nat. Commun. 15, 5752 (2024)

器官发育和成熟是复杂的过程，需要多种分子的动态波动和精确平衡，尤其是在青春期。了解生命过程中各个器官的调节机制对于阐明衰老疾病等基本生物学问题尤其重要。 《自然通讯》的一项研究提出了 C57BL/6JN 雄性和雌性小鼠在三个关键发育阶段（从婴儿期到成年期）的多器官蛋白质组图谱。为了研究小鼠从婴儿期到成年期器官的动态蛋白质变化，研究小组对出生后第 1、4 周分离的 10 个器官（脑、心脏、肺、肝、肾、脾、胃、肠、肌肉和皮肤）进行了蛋白质组分析。 8. 这个包含 >11,000 个蛋白质的图谱显示了 115 个与年龄相关的蛋白质组，为理解驱动器官发育和成熟的分子机制提供了有用的资源。

原文参考： Wang, Q. et al.纳特。交流。 15 , 5752 (2024)