Burst steroid therapy for acute heart failure: The CORTAHF randomized, open-label, pilot trial,European Journal of Heart Failure

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Burst steroid therapy for acute heart failure: The CORTAHF randomized, open-label, pilot trial
European Journal of Heart Failure ( IF 16.9 ) Pub Date : 2024-08-30 , DOI: 10.1002/ejhf.3452
Gad Cotter _{1,

2,

3} , Beth A Davison _{1,

2,

3} , Yonathan Freund _{4,

5} , Adriaan A Voors ₆ , Christopher Edwards ₃ , Maria Novosadova ₃ , Koji Takagi ₃ , Hamlet Hayrapetyan ₇ , Andranik Mshetsyan ₈ , Drambyan Mayranush ₉ , Alain Cohen-Solal _{1,

10} , Jozine M Ter Maaten ₆ , Jan Biegus ₁₁ , Piotr Ponikowski ₁₁ , Gerasimos Filippatos ₁₂ , Ovidiu Chioncel ₁₃ , Malha Sadoune ₁ , Matteo Pagnesi ₁₄ , Tabassome Simon ₄ , Marco Metra ₁₅ , Douglas L Mann ₁₆ , Alexandre Mebazaa _{1,

17}

Affiliation

Université Paris Cité, INSERM UMR-S 942 (MASCOT), Paris, France.
Heart Initiative, Durham, NC, USA.
Momentum Research, Inc, Durham, NC, USA.
IMProving Emergency Care FHU, Sorbonne Université, Paris, France.
Emergency Department and Service Mobile d'Urgence et de Réanimation (SMUR), Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
University of Groningen, Department of Cardiology, University Medical Centre Groningen, Groningen, The Netherlands.
Erebouni Medical Center, Yerevan, Armenia.
'Mikaelyan' Surgery Institute CJSC, Yerevan, Armenia.
'Armenia' Medical Center, Yerevan, Armenia.
Department of Cardiology, APHP Nord, Lariboisière University Hospital, Paris, France.
Institute of Heart Diseases, Wroclaw Medical University, Wrocław, Poland.
National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece.
Emergency Institute for Cardiovascular Diseases 'Prof. C.C. Iliescu', University of Medicine 'Carol Davila', Bucharest, Romania.
Cardiology, ASST Spedali Civili and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
Department of Clinical Pharmacology and Clinical Research Platform Paris-East (URCEST-CRC-CRB), St Antoine Hospital, APHP, Paris, France.
Cardiovascular Division, Department of Medicine, Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, MO, USA.
Department of Anesthesiology and Critical Care and Burn Unit, Saint-Louis and Lariboisière Hospitals, FHU PROMICE, DMU Parabol, APHP Nord, Paris, France.

Burst steroid therapy, effective in acute respiratory diseases, may benefit patients with acute heart failure (AHF) in whom inflammatory activation is associated with adverse outcomes.

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