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Urinary Response to Consuming Plant-Based Meat Alternatives in Persons with Normal Kidney Function: The SWAP-MEAT Pilot Trial
Clinical Journal of the American Society of Nephrology ( IF 8.5 ) Pub Date : 2024-08-26 , DOI: 10.2215/cjn.0000000000000532
Catherine P Ward 1 , Matthew J Landry 1 , Kristen M Cunanan 1 , Kalani L Raphael 2 , Christopher C Dant 1 , Christopher D Gardner 1 , Alan C Pao 3, 4
Affiliation  

Study findings suggest potential benefits of plant-based meat for patients with kidney disease. Background Consuming excess animal meat may exacerbate kidney disorders, such as urinary stone disease and CKD. Plant-based meat alternatives imitate animal meat and replace animal with vegetable protein, but it is unclear whether eating plant-meat confers similar health benefits as eating whole vegetables. We hypothesized that eating plant-meat when compared with animal meat decreases dietary acid load but increases dietary phosphorus and nitrogen. Methods The Study With Appetizing Plantfood—Meat Eating Alternatives Trial was a randomized 8-week, crossover trial (NCT03718988) of participants consuming ≥2 servings/d of either plant-meat or animal meat for each 8-week phase. We measured urine sulfate, ammonium, pH, phosphorus, urea nitrogen (UUN), citrate, and creatinine concentrations and serum creatinine and bicarbonate concentrations from stored participant samples from each phase. Results At a single site, we enrolled 36 generally healthy participants (mean±SD age 50.2±13.8 years, 67% women, and 69% White). Eating the plant-meat diet versus eating the animal meat diet was associated with lower mean concentration of urine sulfate (−6.7 mEq/L; 95% confidence interval [CI], −11.0 to −2.4), urine ammonium (−4.2 mmol/L; 95% CI, −8.2 to −0.1), urine phosphorus (−9.0 mg/dl; 95% CI, −17.5 to −0.5), and UUN (−124.8 mg/dl; 95% CI, −226.9 to −22.6). Eating plant-meat compared with eating animal meat was associated with higher mean urine pH (+0.3 units; 95% CI, 0.2 to 0.5) and mean urine citrate/creatinine ratio (+111.65; 95% CI, 52.69 to 170.60). After participants consumed a plant-meat diet compared with when they consumed an animal meat diet, mean serum creatinine concentration was lower (−0.07 mg/dl, 95% CI, −0.10 to −0.04), whereas mean serum bicarbonate concentration was not different. Conclusions Eating plant-based meat products, compared with eating animal meat, was associated with lower urinary excretion of sulfate, ammonium, phosphorus, and UUN and higher urinary excretion of citrate. Our findings provide rationale for examining whether plant-based meat will benefit patients with kidney disease. Clinical Trial registry name and registration number: NCT03718988....

中文翻译:


肾功能正常的人对食用植物性肉类替代品的尿液反应:SWAP-MEAT 试点试验



研究结果表明,植物肉对肾病患者有潜在益处。背景 食用过量的动物肉可能会加剧肾脏疾病,例如尿路结石病和 CKD。植物性肉类替代品模仿动物肉并用植物蛋白代替动物,但目前尚不清楚吃植物肉是否能带来与吃整个蔬菜相似的健康益处。我们假设与动物肉相比,吃植物肉会降低膳食酸负荷,但会增加膳食磷和氮。方法 开胃植物性食物研究——肉类食用替代品试验是一项为期 8 周的随机交叉试验 (NCT03718988),参与者在每个 8 周阶段食用 ≥2 份/d 的植物肉或动物肉。我们测量了每个阶段储存的参与者样本中的尿硫酸盐、铵、pH 值、磷、尿素氮 (UUN)、柠檬酸盐和肌酐浓度以及血清肌酐和碳酸氢盐浓度。结果 在单个站点,我们招募了 36 名总体健康的参与者 (平均 ±SD 年龄 50.2±13.8 岁,67% 为女性,69% 为白人)。与吃动物肉饮食相比,吃植物肉饮食与较低的尿硫酸盐平均浓度(-6.7 mEq/L;95% 置信区间 [CI],-11.0 至 -2.4)、尿铵(-4.2 mmol/L;95% CI,-8.2 至 -0.1)、尿磷(-9.0 mg/dl;95% CI,-17.5 至 -0.5)和 UUN(-124.8 mg/dl;95% CI、 -226.9 到 -22.6)。与食用动物肉相比,吃植物肉与较高的平均尿 pH 值(+0.3 单位;95% CI,0.2 至 0.5)和平均尿柠檬酸盐/肌酐比值(+111.65;95% CI,52.69 至 170.60)相关。 与食用动物肉饮食相比,参与者食用植物肉后的平均血清肌酐浓度较低(-0.07 mg/dl,95% CI,-0.10 至 -0.04),而平均血清碳酸氢盐浓度没有差异。结论 与食用动物肉相比,食用植物肉产品与硫酸盐、铵、磷和 UUN 的尿排泄量降低以及柠檬酸盐尿排泄量升高有关。我们的研究结果为检查植物肉是否有益于肾病患者提供了理论依据。临床试验注册名称和注册号:NCT03718988....
更新日期:2024-08-26
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