Blood-based multivariate methylation risk score for cognitive impairment and dementia,Alzheimer's & Dementia

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Blood-based multivariate methylation risk score for cognitive impairment and dementia
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2024-08-28 , DOI: 10.1002/alz.14061
Jarno Koetsier _{1,

2} , Rachel Cavill ₃ , Rick Reijnders ₁ , Joshua Harvey ₄ , Jan Homann ₅ , Morteza Kouhsar ₄ , Kay Deckers ₁ , Sebastian Köhler ₁ , Lars M T Eijssen _{1,

6} , Daniel L A van den Hove _{1,

7} , Ilja Demuth _{8,

9} , Sandra Düzel ₁₀ , , Rebecca G Smith ₄ , Adam R Smith ₄ , Joe Burrage ₄ , Emma M Walker ₄ , Gemma Shireby ₄ , Eilis Hannon ₄ , Emma Dempster ₄ , Tim Frayling ₄ , Jonathan Mill ₄ , Valerija Dobricic ₁₁ , Peter Johannsen ₁₂ , Michael Wittig ₁₃ , Andre Franke ₁₃ , Rik Vandenberghe ₁₄ , Jolien Schaeverbeke ₁₄ , Yvonne Freund-Levi _{15,

16,

17} , Lutz Frölich ₁₈ , Philip Scheltens ₁₉ , Charlotte E Teunissen ₂₀ , Giovanni Frisoni ₂₁ , Olivier Blin ₂₂ , Jill C Richardson ₂₃ , Régis Bordet ₂₄ , Sebastiaan Engelborghs _{25,

26} , Ellen de Roeck ₂₅ , Pablo Martinez-Lage ₂₇ , Mikel Tainta ₂₇ , Alberto Lleó ₂₈ , Isabel Sala ₂₈ , Julius Popp ₂₉ , Gwendoline Peyratout ₃₀ , Frans Verhey ₁ , Magda Tsolaki ₃₁ , Ulf Andreasson ₃₂ , Kaj Blennow _{32,

33,

34,

35} , Henrik Zetterberg _{32,

36,

37,

38,

39} , Johannes Streffer ₄₀ , Stephanie J B Vos ₁ , Simon Lovestone ₄₁ , Pieter-Jelle Visser _{1,

17} , Christina M Lill _{5,

42} , Lars Bertram ₁₁ , Katie Lunnon ₄ , Ehsan Pishva _{1,

4}

Affiliation

Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences (FHML), Maastricht University, Maastricht, The Netherlands.
Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Faculty of Health, Medicine and Life Sciences (FHML), Maastricht University, Maastricht, The Netherlands.
Department of Advanced Computing Sciences (DACS), Faculty of Science and Engineering (FSE), Maastricht University, Maastricht, The Netherlands.
Medical School, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK.
Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Department of Bioinformatics - BiGCaT, Research Institute of Nutrition and Translational Research in Metabolism (NUTRIM), Faculty of Health, Medicine and Life Sciences (FHML), Maastricht University, Maastricht, The Netherlands.
Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Dr. Manuel Nagel, Würzburg, Germany.
Department of Endocrinology and Metabolic Diseases (including Division of Lipid Metabolism), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
BCRT - Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.
Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany.
Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, Lübeck, Germany.
Danish Dementia Research Centre, Rigshospitalet, Copenhagen, Denmark.
Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Laboratory for Cognitive Neurology, KU Leuven, Leuven, Belgium.
Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
School of Medical Sciences, Örebro University, Örebro, Sweden.
Department of Geriatrics, Södertälje Hospital, Södertälje, Sweden.
Department of Geriatric Psychiatry, Central Institute of Mental Health; Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Memory Center, Geneva University and University Hospitals; on behalf of the AMYPAD Consortium, Genève, Switzerland.
Aix-Marseille University-CNRS, Marseille, France.
Neuroscience Therapeutic Area, GlaxoSmithKline R&D, Stevenage, Hertfordshire, UK.
Université de Lille, Lille Cedex, France.
Department of Biomedical Sciences, University of Antwerp, Antwerpen, Belgium.
Neuroprotection & Neuromodulation (NEUR) Research Group, Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Jette, Brussels, Belgium.
Center for Research and Advanced Therapies, CITA-Alzheimer Foundation, Gipuzkoa, Spain.
Neurology Department, Centro de Investigación en Red en enfermedades neurodegenerativas (CIBERNED), Hospital Sant Pau, Sant Antoni Maria Claret, Barcelona, Spain.
University Hospital of Psychiatry Zürich, University of Zürich, Zürich, Switzerland.
Department of Psychiatry, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
1st Department of Neurology, School of Medicine, `Laboratory of Neurodegenerative Diseases, Center for Interdisciplinary Research and Innovation, Aristotle University of Thessaloniki, and Alzheimer Hellas, Macedonia, Balkan Center, Thessaloniki, Greece.
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden.
Clinical Neurochemistry Lab, Sahlgrenska University Hospital, Göteborg, Sweden.
Paris Brain Institute, ICM, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France.
Neurodegenerative Disorder Research Center, Division of Life Sciences and Medicine, and Department of Neurology, Institute on Aging and Brain Disorders, University of Science and Technology of China and First Affiliated Hospital of USTC, Hefei, P.R. China.
Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.
UK Dementia Research Institute at UCL, Maple House, London, UK.
Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Shatin, N.T., Hong Kong, China.
Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
AC Immune SA, formerly Janssen R&D, LLC. Beerse, Belgium at the time of study conduct, Lausanne, Switzerland.
University of Oxford, Oxford, United Kingdom; Currently at Johnson & Johnson Innovative Medicines, Beerse, Belgium.
Ageing Epidemiology Research Unit, School of Public Health, Imperial College, South Kensington Campus, London, UK.

The established link between DNA methylation and pathophysiology of dementia, along with its potential role as a molecular mediator of lifestyle and environmental influences, positions blood-derived DNA methylation as a promising tool for early dementia risk detection.

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