Rationale and design of RESILIENCE: A prospective randomized clinical trial evaluating remote ischaemic conditioning for the prevention of anthracycline cardiotoxicity,European Journal of Heart Failure

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Rationale and design of RESILIENCE: A prospective randomized clinical trial evaluating remote ischaemic conditioning for the prevention of anthracycline cardiotoxicity
European Journal of Heart Failure ( IF 16.9 ) Pub Date : 2024-08-30 , DOI: 10.1002/ejhf.3395
Andrea Moreno-Arciniegas ₁ , Alberto García ₂ , Malte Kelm ₃ , Francesco D'Amore ₄ , María Gomes da Silva ₅ , Javier Sánchez-González ₆ , Pedro L Sánchez _{7,

8} , Teresa López-Fernández ₉ , Raul Córdoba ₂ , Riccardo Asteggiano ₁₀ , Vincent Camus ₁₁ , Jouke Smink ₁₂ , Antonio Ferreira ₁₃ , Marie J Kersten ₁₄ , Natacha Bolaños ₁₅ , Noemi Escalera _{1,

8} , Elsa Pacella ₁₆ , Sandra Gómez-Talavera _{1,

2,

8} , Antonio Quesada ₁ , Xavier Rosselló _{1,

8,

17} , Borja Ibanez _{1,

2,

8} ,

Affiliation

Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
IIS-Fundación Jiménez Díaz, Madrid, Spain.
Department of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Düsseldorf, Düsseldorf, Germany.
Aarhus University Hospital, Aarhus, Denmark.
Hematology, Instituto Português de Oncologia de Lisboa (IPO Lisboa), Lisbon, Portugal.
Philips Healthcare Iberia, Madrid, Spain.
Hospital Universitario de Salamanca, Salamanca, Spain.
CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.
Cardiology Department, La Paz University Hospital, IdiPAZ Research Institute, Madrid, Spain.
Faculty of Medicine, Insubria University, Varese, and Laboratorio Analisi e Ricerca Clinica, Turin, Italy.
Centre Henri Becquerel, Department of Hematology and INSERM U1245, Rouen, France.
Department of MR R&D-Clinical Science, Philips, Best, The Netherlands.
Hospital da Luz, Lisbon, Portugal.
Department of Hematology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Lymphoma Coalition Europe, Madrid, Spain.
European Society of Cardiology, Nice, France.
Hospital Universitari Son Espases-IDISBA, Universitat Illes Balears, Palma de Mallorca, Spain.

There is a lack of therapies able to prevent anthracycline cardiotoxicity (AC). Remote ischaemic conditioning (RIC) has shown beneficial effects in preclinical models of AC.

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