Inhibition of myeloperoxidase to treat left ventricular dysfunction in non-ischaemic cardiomyopathy,European Journal of Heart Failure

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Inhibition of myeloperoxidase to treat left ventricular dysfunction in non-ischaemic cardiomyopathy
European Journal of Heart Failure ( IF 16.9 ) Pub Date : 2024-08-30 , DOI: 10.1002/ejhf.3435
Simon Geissen _{1,

2,

3} , Simon Braumann _{1,

2,

3} , Joana Adler ₁ , Felix Sebastian Nettersheim _{1,

3} , Dennis Mehrkens _{1,

2,

3} , Alexander Hof _{1,

3} , Henning Guthoff _{1,

3} , Philipp von Stein ₁ , Sven Witkowski ₄ , Norbert Gerdes ₄ , Frederik Tellkamp _{5,

6} , Marcus Krüger _{5,

6} , Lea Isermann _{2,

5} , Aleksandra Trifunovic ₅ , Alexander C Bunck ₇ , Martin Mollenhauer _{1,

2,

3} , Holger Winkels _{1,

2,

3} , Matti Adam _{1,

2,

3} , Anna Klinke ₈ , Gregor Buch ₉ , Vincent Ten Cate ₉ , Martin Hellmich ₁₀ , Malte Kelm ₄ , Volker Rudolph ₈ , Philipp S Wild ₉ , Stephan Rosenkranz _{1,

2,

3} , Stephan Baldus _{1,

2,

3}

Affiliation

Faculty of Medicine and University Hospital Cologne, Clinic III for Internal Medicine, University of Cologne, Cologne, Germany.
Cologne Cardiovascular Research Center (CCRC), University of Cologne, Cologne, Germany.
Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany.
Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD) and Institute for Mitochondrial Diseases and Ageing, Medical Faculty, University of Cologne, Cologne, Germany.
University of Cologne, Department of Biology, Institute for Genetics, Cologne, Germany.
Department of Radiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Agnes Wittenborg Institute for Translational Cardiovascular Research, Clinic for General and Interventional Cardiology/Angiology, Herz- und Diabeteszentrum NRW, University Hospital of the Ruhr-Universität Bochum, Bad Oeynhausen, Germany.
Preventive Cardiology and Preventive Medicine, Department of Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Institute of Medical Statistics and Computational Biology (IMSB), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Non-ischaemic cardiomyopathy (NICMP), an incurable disease terminating in systolic heart failure (heart failure with reduced ejection fraction [HFrEF]), causes immune activation, however anti-inflammatory treatment strategies so far have failed to alter the course of this disease. Myeloperoxidase (MPO), the principal enzyme in neutrophils, has cytotoxic, pro-fibrotic and nitric oxide oxidizing effects. Whether MPO inhibition ameliorates the phenotype in NICMP remains elusive.

中文翻译：

抑制髓过氧化物酶治疗非缺血性心肌病的左心室功能障碍

非缺血性心肌病（NICMP）是一种以收缩性心力衰竭（射血分数降低的心力衰竭 [HFrEF]）为终点的不治之症，可引起免疫激活，但迄今为止抗炎治疗策略未能改变这种疾病的病程。髓过氧化物酶（MPO）是中性粒细胞中的主要酶，具有细胞毒性、促纤维化和一氧化氮氧化作用。MPO 抑制是否改善 NICMP 中的表型仍然难以捉摸。

更新日期：2024-08-30

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