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The Effects of High-Fat Diet and Flaxseed Oil-Enriched Diet on the Lung Parenchyma of Obese Mice
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2024-08-29 , DOI: 10.1002/mnfr.202300050 Camila de Oliveira Ramos 1 , Marcella Ramos Sant'Ana 1 , Giovana Rios Gonçalves 1 , Thaiane da Silva Rios 1 , Susana Castelo Branco Ramos Nakandakari 1, 2 , Beatriz Burger 3 , Luís Gustavo Romani Fernandes 4 , Ricardo de Lima Zollner 4 , Arthur Noin de Oliveira 5 , Rodrigo Catharino Ramos 5 , Adelino Sanchez Ramos da Silva 6 , José Rodrigo Pauli 7, 8 , Leandro Pereira de Moura 7, 8 , Eduardo Rochete Ropelle 7, 8 , Eli Mansour 9 , Dennys Esper Cintra 1, 2, 8
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2024-08-29 , DOI: 10.1002/mnfr.202300050 Camila de Oliveira Ramos 1 , Marcella Ramos Sant'Ana 1 , Giovana Rios Gonçalves 1 , Thaiane da Silva Rios 1 , Susana Castelo Branco Ramos Nakandakari 1, 2 , Beatriz Burger 3 , Luís Gustavo Romani Fernandes 4 , Ricardo de Lima Zollner 4 , Arthur Noin de Oliveira 5 , Rodrigo Catharino Ramos 5 , Adelino Sanchez Ramos da Silva 6 , José Rodrigo Pauli 7, 8 , Leandro Pereira de Moura 7, 8 , Eduardo Rochete Ropelle 7, 8 , Eli Mansour 9 , Dennys Esper Cintra 1, 2, 8
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Omega-3 (ω3) fatty acids are widely investigated for their anti-inflammatory potential, however, there is little evidence regarding their action in the lung parenchyma in the context of obesity. The objective is to investigate the effects of flaxseed oil (FS), rich in α-linolenic (C18:3 – ω3), on the lungs of obese mice. Mice were fed a high-fat diet (HF) for 8 weeks to induce obesity. Subsequently, a part of these animals received HF containing FS oil for another 8 weeks. The HF consumption induced weight gain and hyperglycemia. The lung parenchyma shows a complete fatty acids profile, compared to the control group (CT). In the lung parenchyma, FS increases the ω3 content and, notwithstanding a reduction in the interleukins (IL) IL1β and IL18 contents compared to HF. However, FS promoted increased alveolar spaces, followed by MCP1 (Monocytes Chemoattractant Protein-1) positive cell infiltration and a dramatic reduction in the anti-inflammatory cytokine, IL10. Despite reducing the pulmonary inflammatory response, the consumption of a food source of ω3 was associated with alterations in the lipid profile and histoarchitecture of the lung parenchyma, which can lead to the development of pulmonary complications. This study brings an alert against the indiscriminate use of ω3 supplements, warranting caution.
中文翻译：
高脂饮食和富含亚麻籽油的饮食对肥胖小鼠肺实质的影响
Omega-3 (ω3) 脂肪酸因其抗炎潜力而被广泛研究，然而，几乎没有证据表明它们在肥胖背景下的肺实质中的作用。目的是研究富含 α-亚麻酸 (C18:3 – ω3) 的亚麻籽油 (FS) 对肥胖小鼠肺部的影响。小鼠被喂食高脂肪饮食（HF）8周以诱导肥胖。随后，其中一部分动物又接受了含有 FS 油的 HF 治疗 8 周。高频消耗导致体重增加和高血糖。与对照组（CT）相比，肺实质显示出完整的脂肪酸谱。在肺实质中，与 HF 相比，FS 增加了 ω3 含量，尽管白细胞介素 (IL) IL1β 和 IL18 含量减少。然而，FS 促进肺泡空间增加，随后 MCP1（单核细胞趋化蛋白-1）阳性细胞浸润以及抗炎细胞因子 IL10 显着减少。尽管减少了肺部炎症反应，但摄入 ω3 食物源与肺实质的脂质谱和组织结构的改变有关，这可能导致肺部并发症的发生。这项研究对滥用 ω3 补充剂发出了警告，需要谨慎行事。
更新日期：2024-08-29
中文翻译：
高脂饮食和富含亚麻籽油的饮食对肥胖小鼠肺实质的影响
Omega-3 (ω3) 脂肪酸因其抗炎潜力而被广泛研究，然而，几乎没有证据表明它们在肥胖背景下的肺实质中的作用。目的是研究富含 α-亚麻酸 (C18:3 – ω3) 的亚麻籽油 (FS) 对肥胖小鼠肺部的影响。小鼠被喂食高脂肪饮食（HF）8周以诱导肥胖。随后，其中一部分动物又接受了含有 FS 油的 HF 治疗 8 周。高频消耗导致体重增加和高血糖。与对照组（CT）相比，肺实质显示出完整的脂肪酸谱。在肺实质中，与 HF 相比，FS 增加了 ω3 含量，尽管白细胞介素 (IL) IL1β 和 IL18 含量减少。然而，FS 促进肺泡空间增加，随后 MCP1（单核细胞趋化蛋白-1）阳性细胞浸润以及抗炎细胞因子 IL10 显着减少。尽管减少了肺部炎症反应，但摄入 ω3 食物源与肺实质的脂质谱和组织结构的改变有关，这可能导致肺部并发症的发生。这项研究对滥用 ω3 补充剂发出了警告，需要谨慎行事。
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