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Garlic Extract Promotes Pancreatic Islet Neogenesis Through α-to-β-Cell Transdifferentiation and Normalizes Glucose Homeostasis in Diabetic Rats
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2024-08-29 , DOI: 10.1002/mnfr.202400362
Amani M Al-Adsani 1 , Khaled K Al-Qattan 1 , Sahar A Barhoush 1 , Manal S Abbood 1 , Suzanne A Al-Bustan 1
Affiliation  

Garlic extract (GE) has been shown to ameliorate hyperglycemia in diabetic rats (DRs) by increasing insulin production. However, the mechanism through which it exerts its effects remains unclear. Here, it investigates the molecular process and the origin of regenerating β-cell in rats with streptozotocin (STZ)-induced diabetes in response to GE.

中文翻译:


大蒜提取物通过 α 到 β 细胞转分化促进胰岛新生,并使糖尿病大鼠的葡萄糖稳态正常化



大蒜提取物 (GE) 已被证明可以通过增加胰岛素的产生来改善糖尿病大鼠 (DR) 的高血糖症。然而,它发挥作用的机制仍不清楚。在这里,它研究了链脲佐菌素 (STZ) 诱导的糖尿病大鼠响应 GE 的分子过程和再生 β 细胞的起源。
更新日期:2024-08-29
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