Facile synthesis of quinoxaline annulated perfluoroalkylated benzoazepine derivatives†,RSC Advances

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Facile synthesis of quinoxaline annulated perfluoroalkylated benzoazepine derivatives†
RSC Advances ( IF 3.9 ) Pub Date : 2016-10-31 00:00:00 , DOI: 10.1039/c6ra22727a
Gang Liu _{1,

2,

3,

4,

5} , Xuechun Sun _{1,

2,

3,

4,

5} , Ling Chen _{1,

2,

3,

4,

5} , Yueci Wu _{1,

2,

3,

4,

5} , Jing Han _{1,

2,

3,

4,

5} , Jie Chen _{1,

2,

3,

4,

5} , Hongmei Deng _{4,

5,

6,

7} , Min Shao _{4,

5,

6,

7} , Hui Zhang _{1,

2,

3,

4,

5} , Weiguo Cao _{1,

2,

3,

4,

5}

Affiliation

Novel perfluoroalkylated benzoazepinoquinoxaline derivatives were synthesized by consecutive intermolecular Michael addition and intramolecular cyclization from 3-(2-aminophenyl)quinoxalin-2(1H)-ones and methyl perfluoroalk-2-ynoates in good yields. This efficient and mild protocol might afford a new pathway for novel drug development.

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