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Facile synthesis of quinoxaline annulated perfluoroalkylated benzoazepine derivatives†
RSC Advances ( IF 3.9 ) Pub Date : 2016-10-31 00:00:00 , DOI: 10.1039/c6ra22727a Gang Liu 1, 2, 3, 4, 5 , Xuechun Sun 1, 2, 3, 4, 5 , Ling Chen 1, 2, 3, 4, 5 , Yueci Wu 1, 2, 3, 4, 5 , Jing Han 1, 2, 3, 4, 5 , Jie Chen 1, 2, 3, 4, 5 , Hongmei Deng 4, 5, 6, 7 , Min Shao 4, 5, 6, 7 , Hui Zhang 1, 2, 3, 4, 5 , Weiguo Cao 1, 2, 3, 4, 5
RSC Advances ( IF 3.9 ) Pub Date : 2016-10-31 00:00:00 , DOI: 10.1039/c6ra22727a Gang Liu 1, 2, 3, 4, 5 , Xuechun Sun 1, 2, 3, 4, 5 , Ling Chen 1, 2, 3, 4, 5 , Yueci Wu 1, 2, 3, 4, 5 , Jing Han 1, 2, 3, 4, 5 , Jie Chen 1, 2, 3, 4, 5 , Hongmei Deng 4, 5, 6, 7 , Min Shao 4, 5, 6, 7 , Hui Zhang 1, 2, 3, 4, 5 , Weiguo Cao 1, 2, 3, 4, 5
Affiliation
Novel perfluoroalkylated benzoazepinoquinoxaline derivatives were synthesized by consecutive intermolecular Michael addition and intramolecular cyclization from 3-(2-aminophenyl)quinoxalin-2(1H)-ones and methyl perfluoroalk-2-ynoates in good yields. This efficient and mild protocol might afford a new pathway for novel drug development.
中文翻译:
喹喔啉环化全氟烷基化苯并氮杂衍生物的简便合成†
通过连续的分子间迈克尔加成反应和3-(2-氨基苯基)喹喔啉-2(1 H)-酮和全氟烷-2-甲基丙烯酸甲酯的分子内环化反应,合成了新型全氟烷基化苯并氮杂萘并喹喔啉衍生物。这种有效和温和的方案可能为新药开发提供一条新途径。
更新日期:2016-10-31
中文翻译:
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喹喔啉环化全氟烷基化苯并氮杂衍生物的简便合成†
通过连续的分子间迈克尔加成反应和3-(2-氨基苯基)喹喔啉-2(1 H)-酮和全氟烷-2-甲基丙烯酸甲酯的分子内环化反应,合成了新型全氟烷基化苯并氮杂萘并喹喔啉衍生物。这种有效和温和的方案可能为新药开发提供一条新途径。