Tunable Nanoislands Decorated Tapered Optical Fibers Reveal Concurrent Contributions in Through-Fiber SERS Detection,ACS Photonics

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Tunable Nanoislands Decorated Tapered Optical Fibers Reveal Concurrent Contributions in Through-Fiber SERS Detection
ACS Photonics ( IF 6.5 ) Pub Date : 2024-08-28 , DOI: 10.1021/acsphotonics.4c00912
Di Zheng _{1,

2} , Muhammad Fayyaz Kashif ₁ , Linda Piscopo _{1,

3} , Liam Collard _{1,

4} , Cristian Ciracì ₁ , Massimo De Vittorio _{1,

3,

4} , Ferruccio Pisanello _{1,

4}

Affiliation

Creating plasmonic nanoparticles on a tapered optical fiber (TF) tip enables a remote surface-enhanced Raman scattering (SERS) sensing probe, ideal for challenging sampling scenarios like biological tissues, site-specific cells, on-site environmental monitoring, and deep brain structures. However, nanoparticle patterns fabricated from current bottom-up methods are mostly random, making geometry control difficult. Uneven statistical distribution, clustering, and multilayer deposition introduce uncertainty in correlating device performance with morphology. Ultimately, this limits the design of the best-performance remote SERS sensing probe. Here we employ a tunable solid-state dewetting method to create densely packed monolayer Au nanoislands with varied geometric parameters in direct contact with the silica TF surface. These patterns exhibit analyzable nanoparticle sizes, densities, and uniform distribution across the entire taper surface, enabling a systematic investigation of particle size, density, and analyte effects on the SERS performance of the through-fiber detection system. The study is focused on the SERS response of a widely employed benchmark molecule, rhodamine 6G (R6G), and serotonin, a highly relevant neurotransmitter for the neuroscience field. The numerical simulations and limit of detection (LOD) experiments on R6G show that the increase of the total near-field enhancement volume promotes the SERS sensitivity of the probe. However, we observed a different behavior for serotonin linked to its interaction with the nanoparticle’s surface. The obtained LOD is as low as 10^–7 M, a value not achieved so far in a through-fiber detection scheme. Therefore, our work offers a strategy to design nanoparticle-based remote SERS sensing probes and provides new clues to discover and understand intricate plasmonic-driven chemical reactions.

中文翻译：

可调谐纳米岛装饰锥形光纤揭示了光纤穿线 SERS 检测的并行贡献

在锥形光纤 (TF) 尖端上创建等离子体纳米颗粒可实现远程表面增强拉曼散射 (SERS) 传感探针，非常适合生物组织、特定位点细胞、现场环境监测和深层脑结构等具有挑战性的采样场景。然而，当前自下而上方法制造的纳米粒子图案大多是随机的，使得几何控制变得困难。不均匀的统计分布、聚类和多层沉积给器件性能与形态的关联带来了不确定性。最终，这限制了最佳性能远程 SERS 传感探头的设计。在这里，我们采用可调固态去湿方法来创建具有不同几何参数的密集单层金纳米岛，与二氧化硅 TF 表面直接接触。这些图案表现出可分析的纳米颗粒尺寸、密度和整个锥形表面的均匀分布，从而能够系统地研究颗粒尺寸、密度和分析物对光纤检测系统 SERS 性能的影响。该研究重点关注广泛使用的基准分子罗丹明 6G (R6G) 和血清素（一种与神经科学领域高度相关的神经递质）的 SERS 响应。 R6G的数值模拟和检测限（LOD）实验表明，总近场增强体积的增加提高了探针的SERS灵敏度。然而，我们观察到血清素的不同行为与其与纳米颗粒表面的相互作用有关。获得的 LOD 低至 10 ^–7 M，这是迄今为止光纤检测方案中未达到的值。因此，我们的工作提供了一种设计基于纳米粒子的远程SERS传感探针的策略，并为发现和理解复杂的等离子体驱动的化学反应提供了新的线索。

更新日期：2024-08-28

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