A total of 360 pigs (DNA 600 × 241; initially 5.8 kg) were used in a 45-d growth study to evaluate the effects of adding 25(OH)D3 with 3 levels of standardized total tract digestible (STTD) P on nursery pig growth performance, bone and urine characteristics, and serum vitamin D. Pigs were weaned at 19 d of age and randomly allotted to 1 of 6 dietary treatments with 5 pigs per pen and 12 replications per treatment. Dietary treatments were arranged in a 2 × 3 factorial with main effects of 25(OH)D3 (0 or 50 µg/kg equivalent to 2,000 IU/kg of vitamin D3; Hy-D, dsm-firmenich, Plainsboro, NJ) and STTD P (70%, 100%, or 130% of the NRC [NRC 2012. Nutrient requirements of swine. 11th rev. ed. Natl. Acad. Press, Washington, DC) requirement estimate on a dietary percentage basis]. All diets contained 1,653 IU/kg of vitamin D3. On day 45, 1 pig per pen was euthanized to collect the right fibula, metacarpal, and 2nd and 10th ribs. Overall, increasing STTD P increased (quadratic, P ≤ 0.003) ADG, ADFI, and G:F with minimal improvement above 100% of the NRC STTD P requirement estimate. Added 25(OH)D3 had no effect on growth performance. Increasing STTD P decreased urinary Ca concentration (linear, P < 0.001) and increased urinary P concentration (quadratic, P < 0.001). When pigs were fed added 25(OH)D3, serum 25(OH)D3 increased (quadratic, P = 0.005) as STTD P increased but no differences were observed when 25(OH)D3 was not added and STTD P increased (25(OH)D3 × STTD P interaction, P = 0.032). When pigs were fed 25(OH)D3, serum 1,25(OH)2D3 increased (quadratic, P < 0.001) as STTD P decreased but the increase was not significant when no 25(OH)D3 was fed (STTD P × 25(OH)D3 interaction, P = 0.002). Bone ash percentage and weight increased (quadratic, P ≤ 0.065) in all bones as STTD P increased. Added 25(OH)D3 had no effect on bone density or bone ash weight; however, the reduction in bone ash percentage observed with reducing STTD P level tended to be less when 25(OH)D3 was provided (linear interaction, P = 0.098). Increasing STTD P decreased the likelihood of abnormal histologic bone lesions in the 10th rib. In summary, added 25(OH)D3 had limited effect on growth performance; however, an increase in serum concentrations of 25(OH)D3 and 24,25(OH)2D3 was observed. The addition of 25(OH)D3 to P-deficient diets increased percentage bone ash. Increasing STTD P to 100% of NRC [NRC 2012. Nutrient requirements of swine. 11th rev. ed. Natl. Acad. Press, Washington, DC] requirement estimate increased growth and 130% of NRC maximized bone ash.

中文翻译：

---

添加具有不同标准化总消化磷浓度的 25（OH）D3 对保育猪生产性能、骨骼特性和血清维生素 D 状态的影响


在一项 45 天生长研究中，共使用了 360 头猪（DNA 600 × 241;初始 5.8 公斤），以评估添加 25（OH）D3 和 3 个水平的标准化总消化道可消化 （STTD） P 对保育猪生长性能、骨骼和尿液特性以及血清维生素 D 的影响。猪在 19 日龄断奶，随机分配到 6 种日粮处理中的 1 种，每栏 5 头猪和 12 头猪每个处理的重复数。饮食处理以 2 × 3 因子排列，主要作用为 25（OH）D3（0 或 50 μg/kg，相当于 2,000 IU/kg 维生素 D3;Hy-D， dsm-firmenich， 普兰斯伯勒， 新泽西州） 和 STTD P（NRC 的 70%、100% 或 130% [NRC 2012.猪的营养需求。第 11 版，国家科学院出版社，华盛顿特区）基于饮食百分比的需求估计]。所有饮食都含有 1,653 IU/kg 的维生素 D3。第 45 天，每栏 1 头猪被安乐死，以收集右腓骨、掌骨以及第 2 和第 10 肋骨。总体而言，增加 STTD P 增加了（二次方，P ≤ 0.003）ADG、ADFI 和 G：F，而超过 NRC STTD P 要求估计值的 100% 的改善最小。添加的 25（OH）D3 对生长性能没有影响。增加 STTD P 降低尿 Ca 浓度 （线性，P < 0.001） 和增加尿 P 浓度 （二次方，P < 0.001）。当猪饲喂添加 25（OH）D3 时，血清 25（OH）D3 随着 STTD P 的增加而增加（二次方，P = 0.005），但当不添加 25（OH）D3 且 STTD P 增加时未观察到差异（25（OH）D3 × STTD P 交互作用，P = 0.032）。当猪饲喂 25（OH）D3 时，血清 1,25（OH）2D3 随着 STTD P 的降低而增加 （二次方，P < 0.001），但当不饲喂 25（OH）D3 时，增加不显著 （STTD P × 25（OH）D3 相互作用，P = 0.002）。骨灰百分比和重量增加（二次方，P ≤ 0。065） 在所有骨骼中，因为 STTD P 增加。添加的 25（OH）D3 对骨密度或骨灰重量没有影响;然而，当提供 25（OH）D3 时，通过降低 STTD P 水平观察到的骨灰百分比降低往往较小 （线互作用，P = 0.098）。增加 STTD P 降低了第 10 肋组织学骨病变异常的可能性。总之，添加的 25（OH）D3 对生长性能的影响有限;然而，观察到 25（OH）D3 和 24,25（OH）2D3 的血清浓度增加。在 P 缺陷饮食中添加 25（OH）D3 增加了骨灰的百分比。将 STTD P 提高到 NRC 的 100% [NRC 2012.猪的营养需求。第 11 版，国家科学院出版社，华盛顿特区] 需求估计增加，NRC 的 130% 使骨灰最大化。