Hyperthermia plays a significant role in cancer treatment by inducing cell damage through temperature elevation, often used alongside other treatment modalities. During hyperthermia therapy, temperature control is crucial. Here, we report on a simple synthesis route of hybrid plasmonic nanodiamonds either completely wrapped with an Au shell (NV@Au) or densely covered with Au NPs (NV@SiO 2 @Au). Such integration of nanodiamonds with Au NPs is advantageous both for heating and precise thermometry at nanoscale. After structural and optical investigations, heating abilities of the obtained plasmonic nanodiamonds were thoroughly inspected on glass, in association with living cells, and in tissue slices ex vivo, revealing their effective heat generation under excitation with light using a single excitation source. The developed hybrid plasmonic nanodiamonds were finally applied for local photothermal therapy of melanoma in vivo, demonstrating their efficacy in eradicating cancer cells and monitoring temperature during the process.

中文翻译：

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用于黑色素瘤测温和局部光热治疗的混合等离子体纳米金刚石：比较研究


热疗通过升高温度诱导细胞损伤，在癌症治疗中发挥着重要作用，通常与其他治疗方式一起使用。在热疗过程中，温度控制至关重要。在这里，我们报告了一种简单的混合等离子体纳米金刚石的合成路线，该金刚石要么完全包裹着金壳（NV@Au），要么密集地覆盖着金纳米粒子（NV@SiO 2 @Au）。纳米金刚石与金纳米粒子的这种集成对于纳米级的加热和精确测温都是有利的。经过结构和光学研究后，在玻璃上、与活细胞相关的以及离体组织切片中彻底检查了所获得的等离子体纳米金刚石的加热能力，揭示了它们在使用单一激发源的光激发下的有效产热能力。开发的混合等离子体纳米金刚石最终应用于体内黑色素瘤的局部光热治疗，证明了其在消灭癌细胞和监测过程中温度的功效。