Alzheimer's disease CSF biomarkers correlate with early pathology and alterations in neuronal and glial gene expression,Alzheimer's & Dementia

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Alzheimer's disease CSF biomarkers correlate with early pathology and alterations in neuronal and glial gene expression
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2024-08-27 , DOI: 10.1002/alz.14194
Ali S Ropri _{1,

2} , Tiffany G Lam _{1,

2} , Vrinda Kalia ₃ , Heather M Buchanan _{1,

2} , Anne Marie W Bartosch _{1,

2} , Elliot H H Youth _{1,

2} , Harrison Xiao _{1,

2} , Sophie K Ross _{1,

2} , Anu Jain ₄ , Jayanta K Chakrabarty ₄ , Min Suk Kang _{2,

5} , Deborah Boyett ₆ , Eleonora F Spinazzi ₆ , Gail Iodice ₇ , Robert A McGovern ₈ , Lawrence S Honig _{2,

5} , Lewis M Brown ₄ , Gary W Miller ₃ , Guy M McKhann ₆ , Andrew F Teich _{1,

2,

5}

Affiliation

Normal pressure hydrocephalus (NPH) patients undergoing cortical shunting frequently show early Alzheimer's disease (AD) pathology on cortical biopsy, which is predictive of progression to clinical AD. The objective of this study was to use samples from this cohort to identify cerebrospinal fluid (CSF) biomarkers for AD-related central nervous system (CNS) pathophysiologic changes using tissue and fluids with early pathology, free of post mortem artifact.

中文翻译：

阿尔茨海默病 CSF 生物标志物与早期病理以及神经元和神经胶质细胞基因表达的改变相关

接受皮质分流术的正常压力脑积水（NPH）患者在皮质活检中经常显示早期阿尔茨海默病（AD）病理，这可预测进展为临床 AD。本研究的目的是使用来自该队列的样本，使用具有早期病理学的组织和液体确定 AD 相关中枢神经系统（CNS）病理生理变化的脑脊液（CSF）生物标志物，无死后伪影。

更新日期：2024-08-27

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